{"id":"W3015941631","doi":"10.1002/mus.26887","title":"Guidelines on clinical presentation and management of nondystrophic myotonias","year":2020,"lang":"en","type":"review","venue":"Muscle & Nerve","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Wellcome Trust; Advanced Foods and Materials Canada","keywords":"Mexiletine; Myotonia; Myotonia congenita; Medicine; Channelopathy; Weakness; Muscle relaxation; Muscle weakness; Anesthesia; Internal medicine; Surgery; Myotonic dystrophy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001571097,0.000333255,0.0009288089,0.00008860336,0.00005313692,0.00004296744,0.0003625838,0.00009519082,0.0000231952],"category_scores_gemma":[0.0004160164,0.0002727315,0.0003582102,0.000291732,0.0001120844,0.00003842748,0.0002689797,0.0001975613,0.00006564798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001601251,"about_ca_system_score_gemma":0.00006684379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004164832,"about_ca_topic_score_gemma":6.505253e-7,"domain_scores_codex":[0.9969218,0.0005817971,0.001012214,0.0008873385,0.0004042787,0.0001926099],"domain_scores_gemma":[0.998588,0.0002650952,0.0004733677,0.0004611808,0.00006102661,0.0001513695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001210956,0.0001120397,0.000005939167,0.006013945,0.00003228448,0.0001325704,0.000009617038,0.00001287394,0.0001425419,0.0006074577,0.002018946,0.9908997],"study_design_scores_gemma":[0.0003743772,0.0003729557,0.0003485905,0.002888218,0.0005116346,0.000005890247,0.000007471009,0.00008774874,0.0008452494,0.00003312578,0.9942488,0.0002759387],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00555863,0.9907782,0.00003005544,0.0002719627,0.0005566333,0.001750582,0.0002020231,0.00007643749,0.0007754799],"genre_scores_gemma":[0.0007253985,0.9979142,0.0004363052,0.0002976396,0.0002010743,0.0001217569,0.00001838129,0.00005112099,0.0002341223],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9922299,"threshold_uncertainty_score":0.9999725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3165302670412412,"score_gpt":0.4606781117328295,"score_spread":0.1441478446915883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}