{"id":"W3015946536","doi":"10.2147/ndt.s235395","title":"<p>APOE ϵ4 Allele Is Associated with Elevated Levels of CSF VILIP-1 in Preclinical Alzheimer’s Disease</p>","year":2020,"lang":"en","type":"article","venue":"Neuropsychiatric Disease and Treatment","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Key Research and Development Program of China; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Shanghai Municipal Education Commission; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Medicine; Cerebrospinal fluid; Biomarker; Disease; Alzheimer's disease; Neuroimaging; Immunology; Pathology; Internal medicine; Psychiatry; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002786883,0.000727878,0.0003497522,0.0008786011,0.0004694868,0.0005219175,0.0002914192,0.0005509492,0.002703082],"category_scores_gemma":[0.0008442328,0.0002817997,0.0003305691,0.0004797768,0.0004453487,0.0002604955,0.0002272783,0.0004855773,0.0003885472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002023047,"about_ca_system_score_gemma":0.0002007134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002407893,"about_ca_topic_score_gemma":0.00160072,"domain_scores_codex":[0.9998785,0.00002043984,0.00001909324,0.00003338821,0.00002411808,0.00002451962],"domain_scores_gemma":[0.9993047,0.00009221084,0.0004043981,0.00002965771,0.00005947218,0.0001095975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005424929,0.0003202602,0.9477682,0.00005299205,0.0001699834,0.005402862,0.0002579363,0.0001027596,0.03512039,0.0001364438,0.000335222,0.004908071],"study_design_scores_gemma":[0.00003497391,0.0004902845,0.9891824,0.00001457046,0.0001414618,0.006100775,0.0001881999,0.0004738057,0.002896493,0.0001584628,0.0003080889,0.0000105332],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994392,0.0001036393,0.00009067976,0.0000351478,0.000008460052,0.000003065063,0.00005353041,0.000007488233,0.0002588716],"genre_scores_gemma":[0.9992377,0.00004622108,0.0001356882,0.00001790478,0.00001087157,0.00000260513,0.00007679077,0.000004768445,0.0004675584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002703082,"threshold_uncertainty_score":0.00904268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06174948351953145,"score_gpt":0.3237346363274965,"score_spread":0.261985152807965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}