{"id":"W3015959740","doi":"10.7554/elife.51977","title":"Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Aging; Robert A. and Renee E. Belfer Family Foundation; National Cancer Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Alzheimer's Association; Burroughs Wellcome Fund; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Retromer; Cell biology; Biology; GTPase; Endosome; Neuroscience; Proteostasis; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076103,0.0004136052,0.0002432883,0.0002676035,0.0002832448,0.0003418895,0.0002773328,0.00028696,0.001029851],"category_scores_gemma":[0.0001156347,0.0001529364,0.0002196952,0.0001373347,0.0003573757,0.0002690853,0.0003035546,0.0004130796,0.0005040908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003899028,"about_ca_system_score_gemma":0.0002584792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000830887,"about_ca_topic_score_gemma":0.0012229,"domain_scores_codex":[0.9999139,0.000007290851,0.00001010927,0.00002721838,0.0000229967,0.0000184228],"domain_scores_gemma":[0.999864,0.000007157192,0.00004666208,0.00000982996,0.00001515896,0.00005723988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001210306,0.000007032221,0.000306257,0.00001370152,0.00000285808,0.0001206558,0.000008636311,0.0000361253,0.9986709,0.00008648093,0.00004194186,0.0005844153],"study_design_scores_gemma":[0.00003033695,0.0001353305,0.0416519,0.00001534721,0.00002782463,0.001178405,0.00016521,0.001706598,0.9514033,0.0003658042,0.003309359,0.00001064397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995021,0.001591784,0.001639211,0.0001263337,0.0000307991,0.000006653553,0.0005210069,0.00009314137,0.000970069],"genre_scores_gemma":[0.9946261,0.0008186967,0.001113322,0.00003291654,0.000006509738,0.00001135812,0.0006889366,0.000037694,0.002664422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001029851,"threshold_uncertainty_score":0.003445208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591620856641494,"score_gpt":0.2269593344059697,"score_spread":0.2110431258395547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}