{"id":"W3015988030","doi":"10.1016/j.cellsig.2020.109627","title":"SMURF2 and SMAD7 induce SARA degradation via the proteasome","year":2020,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"MG132; Ubiquitin ligase; SMAD; Proteasome; Cell biology; Smad2 Protein; Signal transduction; Ubiquitin; Phosphorylation; Receptor; Chemistry; Gene silencing; Biology; Proteasome inhibitor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003181773,0.000600658,0.0003471895,0.0004583795,0.0003103929,0.0005301746,0.000197459,0.0004236246,0.003241687],"category_scores_gemma":[0.0001721643,0.0002538362,0.0007531819,0.0001395448,0.0002789784,0.0003005556,0.0003109486,0.0008679074,0.001358763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005361115,"about_ca_system_score_gemma":0.0004026811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000722553,"about_ca_topic_score_gemma":0.001284002,"domain_scores_codex":[0.9997337,0.00003436942,0.0000191424,0.00004498419,0.00006501297,0.0001026824],"domain_scores_gemma":[0.9998243,0.00002282792,0.00004789935,0.00002160041,0.00002928367,0.00005402006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005767681,0.00005463363,0.000276257,0.00009455306,0.00002842341,0.0001445792,0.00001429819,0.00006843698,0.9957695,0.0003273217,0.0002807672,0.00236452],"study_design_scores_gemma":[0.00004585862,0.0001871919,0.005386536,0.000007651482,0.00001645748,0.0004476707,0.00004517387,0.0007032335,0.9886192,0.0001175725,0.004415856,0.000007551327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721015,0.0125178,0.004830415,0.0009239962,0.0002663607,0.00006544522,0.0008604849,0.0003047853,0.008129146],"genre_scores_gemma":[0.987086,0.00195417,0.001852173,0.0001897573,0.00005369047,0.00004889473,0.00104427,0.00003203132,0.007738971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003241687,"threshold_uncertainty_score":0.01084453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01986892059744862,"score_gpt":0.2163636126350802,"score_spread":0.1964946920376316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}