{"id":"W3016001416","doi":"10.1001/jamaneurol.2020.0414","title":"Association of<i>Klotho</i>-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry<i>APOE4</i>","year":2020,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; National Institutes of Health; Servier; Eisai; Northern California Institute for Research and Education; H. Lundbeck A/S; Rush University; Oregon Health and Science University; Meso Scale Diagnostics; Eli Lilly and Company; University of Miami; F. Hoffmann-La Roche; Vanderbilt University; Genentech; IXICO; University of Pittsburgh; Pfizer; University of Southern California; Canadian Institutes of Health Research; University of Washington; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Alzheimer's disease; Oncology; Internal medicine; Logistic regression; Psychology; Medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001142314,0.0001340122,0.0004803137,0.0000703801,0.00001993841,0.000003881091,0.00006678646,0.0001351971,0.00001162644],"category_scores_gemma":[0.0002189978,0.0001096234,0.00008168235,0.0002164742,0.00005287419,0.00006387625,0.00004058902,0.0002751452,0.000009672282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001039263,"about_ca_system_score_gemma":0.00006589171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001872436,"about_ca_topic_score_gemma":0.0000644633,"domain_scores_codex":[0.9988011,0.0002154164,0.0002858818,0.0002666146,0.0002306629,0.0002003876],"domain_scores_gemma":[0.9991777,0.0001114925,0.0003108069,0.0001856448,0.00006328138,0.0001511062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001439621,0.0003222994,0.9942822,0.00001512738,0.0002815958,0.00007857545,0.0003830487,0.0000976522,0.0002393129,0.00001470553,0.002694828,0.0001510545],"study_design_scores_gemma":[0.005859354,0.001568892,0.9895735,0.000006605226,0.0006608154,0.000003055632,0.000007836723,0.0002284283,0.0009846382,0.00004889057,0.0009858627,0.00007215924],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904892,0.001043423,0.00001215652,0.007469014,0.00003166108,0.0003491496,0.0001471498,0.00001731657,0.0004409354],"genre_scores_gemma":[0.9960834,0.000177497,0.00005001023,0.00355644,0.00004143861,0.00001738624,0.00003425762,0.00001621348,0.00002329957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005594263,"threshold_uncertainty_score":0.4470314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01345272311859671,"score_gpt":0.2486772224272836,"score_spread":0.2352244993086869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}