{"id":"W3016036364","doi":"10.3389/fnagi.2020.00083","title":"Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss","year":2020,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Horizon 2020; Horizon 2020 Framework Programme; Eberhard Karls Universität Tübingen; Deutsche Forschungsgemeinschaft","keywords":"Knockout mouse; Internal medicine; Endocrinology; Cyclic guanosine monophosphate; Hair cell; Spiral ganglion; Hearing loss; Phosphodiesterase; Inner ear; Cochlea; Biology; Signal transduction; Gene knockout; Receptor; Chemistry; Cell biology; Medicine; Gene; Neuroscience; Enzyme; Audiology; Genetics; Nitric oxide; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001554846,0.0004801606,0.0003188377,0.0002940838,0.0001248762,0.0002253774,0.0002089889,0.0003797938,0.001001157],"category_scores_gemma":[0.0001476186,0.0001680211,0.0002943661,0.00007812824,0.0003658483,0.0003604405,0.0003306365,0.0006637226,0.0002086498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001614091,"about_ca_system_score_gemma":0.0001488365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000299037,"about_ca_topic_score_gemma":0.0004895033,"domain_scores_codex":[0.9998628,0.0000116499,0.00001411634,0.00004301167,0.0000321316,0.00003627083],"domain_scores_gemma":[0.9997814,0.00001481706,0.00009064518,0.00001891805,0.00001398833,0.00008026131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000120254,0.00001586098,0.0001929753,0.00001451402,0.000002499389,0.0000361914,0.000009471421,0.00001350689,0.9985996,0.00003303795,0.00001489973,0.0009471484],"study_design_scores_gemma":[0.00003460346,0.001552024,0.02460282,0.00001424556,0.00004278894,0.0006385972,0.0000692492,0.0007966761,0.9705466,0.0002400767,0.001451962,0.00001033862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996219,0.001322948,0.001668477,0.00008947583,0.00003135926,0.00001216156,0.000126942,0.0001316994,0.000397982],"genre_scores_gemma":[0.9960724,0.001015807,0.001272416,0.00004956355,0.00001471419,0.0000180102,0.0001354296,0.00002290656,0.00139882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001157,"threshold_uncertainty_score":0.003349185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06486467917783033,"score_gpt":0.2803724396234524,"score_spread":0.2155077604456221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}