{"id":"W3016037674","doi":"10.1101/2020.04.10.035410","title":"XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fonds De La Recherche Scientifique - FNRS; Université du Luxembourg","keywords":"RAD51; RAD52; Homologous recombination; DNA repair; Replication protein A; DNA damage; Synthetic lethality; DNA; Biology; DNA repair protein XRCC4; Homologous chromosome; Temozolomide; Molecular biology; Chemistry; Cell biology; Cancer research; Nucleotide excision repair; Genetics; DNA-binding protein; Glioblastoma; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268616,0.000388154,0.0002416428,0.000195212,0.0001095,0.0002765315,0.000201712,0.0002222997,0.002454878],"category_scores_gemma":[0.00008347288,0.0001789375,0.0001809011,0.0001159466,0.0001755376,0.0001071315,0.0001829759,0.0004719313,0.0007425899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739895,"about_ca_system_score_gemma":0.0001545967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004148835,"about_ca_topic_score_gemma":0.0005257304,"domain_scores_codex":[0.9998944,0.00001926305,0.000008120028,0.00001769315,0.00003348466,0.00002709241],"domain_scores_gemma":[0.9999262,0.000009288369,0.00002060911,0.00001206308,0.000006135655,0.00002576373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007739507,0.00002047845,0.00006318959,0.00001610344,0.000003647298,0.00002811789,0.000002978956,0.00003452885,0.999156,0.00005414508,0.00004331078,0.0005001056],"study_design_scores_gemma":[0.00001103585,0.0001039593,0.001258569,0.000002643578,0.000003865073,0.000102752,0.000003934797,0.0002860312,0.9966438,0.0000119802,0.001570177,0.000001280403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915761,0.002029798,0.00277357,0.0001307609,0.00004392268,0.00002263807,0.0005725307,0.0002090659,0.002641477],"genre_scores_gemma":[0.9904785,0.0006446164,0.001596109,0.00003038409,0.0000121732,0.00002605985,0.0010166,0.0000664352,0.006129129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002454878,"threshold_uncertainty_score":0.008212388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201522566071083,"score_gpt":0.225217264240481,"score_spread":0.2132020385797702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}