{"id":"W3016050178","doi":"10.1371/journal.pgen.1008629","title":"A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Bayer HealthCare; British Heart Foundation; National Institute for Health and Care Research; National Institute of General Medical Sciences; Sanofi","keywords":"Missense mutation; Cirrhosis; Biology; Hepatology; Internal medicine; Liver disease; Fatty liver; Alanine transaminase; Endocrinology; Gastroenterology; Gene; Disease; Genetics; Medicine; Biochemistry; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003857345,0.0004150759,0.0003423814,0.0006994175,0.0003425384,0.0003066521,0.0002781383,0.0004459939,0.002064583],"category_scores_gemma":[0.001439089,0.0001549286,0.0003564918,0.0004990779,0.0002617183,0.0001223894,0.000250985,0.0002525026,0.0001392353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001483078,"about_ca_system_score_gemma":0.0001381812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002138058,"about_ca_topic_score_gemma":0.002082795,"domain_scores_codex":[0.9997094,0.0000728926,0.00003039216,0.0001033162,0.0000444835,0.00003944073],"domain_scores_gemma":[0.999427,0.000191532,0.0002052884,0.00004282458,0.00003744339,0.00009605739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001501995,0.00009586308,0.9792374,0.0000295839,0.0004150998,0.002165941,0.0001166398,0.0001718939,0.01041171,0.0001163443,0.0002342875,0.005503275],"study_design_scores_gemma":[0.000083848,0.0004545999,0.9924965,0.00001053584,0.0002627263,0.004092147,0.00009030682,0.0007412747,0.001200953,0.0001202266,0.0004385799,0.000008279613],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993692,0.0002013395,0.0001345333,0.0000287269,0.000006690172,0.000002911725,0.00007912093,0.00000586384,0.0001716636],"genre_scores_gemma":[0.9995927,0.00004388974,0.000091701,0.00001561585,0.00001098451,0.000001616122,0.0000757449,0.000001716486,0.000166168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002138058,"threshold_uncertainty_score":0.006906748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03926712627868469,"score_gpt":0.2298146544479066,"score_spread":0.1905475281692219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}