{"id":"W3016074620","doi":"10.1101/2020.04.13.039735","title":"Distinct CD8 <sup>+</sup> T Cell Programming in the Tumor Microenvironment Contributes to Sex Bias in Bladder Cancer Outcome","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of South Carolina; Canadian Institutes of Health Research; Hollings Cancer Center, Medical University of South Carolina; Medical University of South Carolina","keywords":"Cytotoxic T cell; CD8; Biology; Progenitor cell; Immunology; Cancer research; Tumor microenvironment; Bladder cancer; Immune system; T cell; Immunotherapy; Cancer; Stem cell; Cell biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003559666,0.0002283586,0.0002543627,0.0003359988,0.000113836,0.0006075256,0.0001795884,0.0002255862,0.003782082],"category_scores_gemma":[0.000361957,0.000123109,0.0001486222,0.0002037628,0.000220251,0.0001567466,0.0002631249,0.0003240176,0.0008876455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001292048,"about_ca_system_score_gemma":0.0001364132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001922326,"about_ca_topic_score_gemma":0.0002335639,"domain_scores_codex":[0.9998123,0.00003698723,0.00001315012,0.000050355,0.00003705731,0.00005019969],"domain_scores_gemma":[0.9997004,0.00004435762,0.0001392544,0.00003442066,0.00002036942,0.00006115114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004020616,0.0002452255,0.4240011,0.0002624494,0.0001138673,0.001202093,0.0002083871,0.0004257134,0.5041162,0.0008733385,0.001523307,0.06300773],"study_design_scores_gemma":[0.00003519888,0.0007958283,0.9340045,0.00004084349,0.00007980761,0.003640763,0.0002048037,0.001335396,0.05604601,0.0008190111,0.002976496,0.00002139469],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920142,0.003202044,0.001362448,0.0002279104,0.00003347813,0.00001778914,0.0008959498,0.00005395009,0.002192251],"genre_scores_gemma":[0.9975447,0.0005493519,0.0002750565,0.00009213575,0.00003932066,0.00001573865,0.0003851972,0.00002424144,0.00107418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003782082,"threshold_uncertainty_score":0.01265234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02371435983716567,"score_gpt":0.2373441434296439,"score_spread":0.2136297835924783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}