{"id":"W3016154560","doi":"10.1101/2020.04.10.20059121","title":"ACE inhibition and cardiometabolic risk factors, lung <i>ACE2</i> and <i>TMPRSS2</i> gene expression, and plasma ACE2 levels: a Mendelian randomization study","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; St. Paul's Hospital; University of British Columbia","funders":"NIHR BioResource; University of Cambridge; National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust; NHS Blood and Transplant; Medical Research Council; Biogen; Princeton University; NIHR Cambridge Biomedical Research Centre; Sanofi; AstraZeneca; Cambridge University Hospitals; Pfizer","keywords":"Mendelian randomization; Expression quantitative trait loci; TMPRSS2; Internal medicine; Genome-wide association study; Medicine; Biology; Endocrinology; Bioinformatics; Genetics; Disease; Genotype; Single-nucleotide polymorphism; Gene; Genetic variants; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00102216,0.0007844964,0.002193135,0.000376907,0.0003424493,0.0001607116,0.000103554,0.0004114987,0.000005752207],"category_scores_gemma":[0.0008068907,0.0006193437,0.0001726853,0.0003453512,0.0001961162,0.0001413735,0.001191037,0.0007537815,0.000002563252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006949567,"about_ca_system_score_gemma":0.00008720348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001506879,"about_ca_topic_score_gemma":0.00002479832,"domain_scores_codex":[0.9957725,0.0007629356,0.0008880385,0.001433667,0.0007441152,0.0003987181],"domain_scores_gemma":[0.9977072,0.000299077,0.0006195051,0.0006648962,0.0002962432,0.0004130796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008642913,0.0001202586,0.9220436,0.0005001813,0.001385596,0.0001153627,0.01305436,0.00005552858,0.05922763,0.000002078783,0.001947215,0.0006838578],"study_design_scores_gemma":[0.03149118,0.0004785435,0.9036881,0.00152572,0.005203616,0.0002232538,0.003073289,0.001640746,0.04936356,0.00008377079,0.001885327,0.001342858],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816969,0.01154144,0.001139673,0.0007996022,0.0005712492,0.003665092,0.0003024731,0.0001996813,0.00008387197],"genre_scores_gemma":[0.9928018,0.004820951,0.00123834,0.00007878355,0.0005387996,0.000198565,0.0001157535,0.0001130478,0.00009394397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03062689,"threshold_uncertainty_score":0.9996258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03320060432696778,"score_gpt":0.2767891159737491,"score_spread":0.2435885116467813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}