{"id":"W3016186533","doi":"10.5772/intechopen.91915","title":"Repurposing Fumaric Acid Esters to Treat Conditions of Oxidative Stress and Inflammation: A Promising Emerging Approach with Broad Potential","year":2020,"lang":"en","type":"book-chapter","venue":"IntechOpen eBooks","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Dimethyl fumarate; Psoriasis; Oxidative stress; Repurposing; Fumaric acid; Medicine; Inflammation; Pharmacology; Chemistry; Multiple sclerosis; Dermatology; Biology; Biochemistry; Immunology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001391418,0.0004278,0.0008429096,0.0004169942,0.0001900954,0.00009052338,0.0001760891,0.0001722728,0.00005605592],"category_scores_gemma":[0.0001314598,0.0003519679,0.0001174031,0.0000568108,0.00042032,0.0001026458,0.0004000627,0.0005913269,0.000008180625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001604916,"about_ca_system_score_gemma":0.0001728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006711289,"about_ca_topic_score_gemma":0.00003004693,"domain_scores_codex":[0.9978743,0.0000395851,0.0005365393,0.0006535414,0.0006207161,0.0002753525],"domain_scores_gemma":[0.9985301,0.00006527301,0.0003276155,0.0004122907,0.0004078028,0.0002569033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006208818,0.000187172,0.0004269901,0.008032052,0.005262385,0.000673523,0.02755988,0.0001539201,0.5318073,0.007621551,0.001260585,0.4108058],"study_design_scores_gemma":[0.02501429,0.01067563,0.002390728,0.07181661,0.006561277,0.001117531,0.01753681,0.002242447,0.8295935,0.002207611,0.02524152,0.005602044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.02193021,0.0004363139,0.006888893,0.0009360099,0.0000718285,0.00735355,0.0003216697,0.000191848,0.9618697],"genre_scores_gemma":[0.8775171,0.0001862034,0.02446451,0.0002325952,0.0005276756,0.0005889746,0.0004435968,0.0002846682,0.09575465],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.866115,"threshold_uncertainty_score":0.9998932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03741519876328607,"score_gpt":0.2945737388780956,"score_spread":0.2571585401148095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}