{"id":"W3016356347","doi":"10.1007/s11910-020-01032-8","title":"Pathophysiology of Conversion to Symptomatic Leber Hereditary Optic Neuropathy and Therapeutic Implications: a Review","year":2020,"lang":"en","type":"review","venue":"Current Neurology and Neuroscience Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"","keywords":"Mitophagy; Optic neuropathy; Neuroscience; Mitochondrion; Leber's hereditary optic neuropathy; Retinal ganglion cell; Biology; Optic nerve; mitochondrial fusion; Retina; Mitochondrial disease; Medicine; Bioinformatics; Mitochondrial DNA; Genetics; Autophagy; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005045477,0.001005379,0.00151336,0.002132288,0.0002279455,0.001135768,0.001002351,0.001240209,0.002454469],"category_scores_gemma":[0.000655418,0.0002314389,0.0004244029,0.001666515,0.0005094442,0.001264527,0.0007109204,0.001212949,0.001060902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005618581,"about_ca_system_score_gemma":0.0009692462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007721282,"about_ca_topic_score_gemma":0.001447884,"domain_scores_codex":[0.9998776,0.00001994034,0.00002493439,0.00002867124,0.00003441825,0.00001444868],"domain_scores_gemma":[0.9997724,0.000114692,0.00003962985,0.000005620439,0.00004276696,0.00002486931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001967185,0.00009170501,0.0004287675,0.02275114,0.000164647,0.001502486,0.00007697087,0.0004721598,0.00197322,0.003160203,0.04435547,0.9248264],"study_design_scores_gemma":[0.00006266215,0.0001622921,0.001969582,0.007589204,0.0004234246,0.009429797,0.0001705369,0.0001914949,0.0005459091,0.004313845,0.9750933,0.00004797492],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008960942,0.9992061,0.00008388927,0.0001720622,0.0001442288,0.000002458479,0.00001236658,0.00000443811,0.0002847616],"genre_scores_gemma":[0.0005557321,0.9986845,0.0001402449,0.0001554282,0.0002376058,0.000003808897,0.00002143238,8.374166e-7,0.0002003507],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002454469,"threshold_uncertainty_score":0.008210957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03842820881524307,"score_gpt":0.3228157134060458,"score_spread":0.2843875045908027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}