{"id":"W3016420530","doi":"10.1101/2020.04.17.047217","title":"Discovery of <i>Plasmodium falciparum</i> SR12 as a GOLD-Domain seven transmembrane protein regulating GPCR trafficking in mammalian cells","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Alliance de recherche numérique du Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Thrombin; G protein-coupled receptor; Receptor; HEK 293 cells; Cell biology; Thrombin receptor; Biology; Plasmodium falciparum; Muscarinic acetylcholine receptor; Urokinase receptor; Signal transduction; Chemistry; Biochemistry; Platelet; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156611,0.0001815576,0.0002198657,0.0000877664,0.0001392234,0.0002290179,0.0001793786,0.0002381422,0.0005135782],"category_scores_gemma":[0.00007291696,0.00009827693,0.0001950148,0.0000988052,0.0001291317,0.0001103193,0.0001405443,0.0003315279,0.0003757476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002685194,"about_ca_system_score_gemma":0.0001397682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004931192,"about_ca_topic_score_gemma":0.0007085554,"domain_scores_codex":[0.9999473,0.00001145609,0.000003738088,0.00001180625,0.00001541818,0.00001033545],"domain_scores_gemma":[0.9999716,0.000003960916,0.00000655005,0.000003448104,0.000006547951,0.000007864634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003973228,0.000006344495,0.0001375795,0.00004395644,0.000002929531,0.00006512407,0.000008639858,0.00006226313,0.9982554,0.0002615011,0.0001711367,0.0009452336],"study_design_scores_gemma":[0.00002149595,0.0002805375,0.002995105,0.0000132433,0.00001604716,0.0005522728,0.00003893939,0.002351719,0.977966,0.0001329084,0.01562402,0.000007672236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737558,0.004279555,0.01459313,0.001078845,0.00007269262,0.0001106048,0.001293278,0.0003780604,0.004437973],"genre_scores_gemma":[0.9796158,0.003500702,0.0122536,0.0002076924,0.00002148223,0.00005470106,0.001331266,0.00004493497,0.002969866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005135782,"threshold_uncertainty_score":0.001948237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01009813571436024,"score_gpt":0.2083834040196846,"score_spread":0.1982852683053244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}