{"id":"W3016439079","doi":"10.3390/molecules25081872","title":"Synthesis and Evaluation of [18F]FEtLos and [18F]AMBF3Los as Novel 18F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Graduate Education; Fundação de Amparo à Pesquisa do Estado de São Paulo; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Government of Canada","keywords":"Losartan; Biodistribution; Chemistry; Losartan Potassium; Angiotensin II; In vivo; Angiotensin receptor; Receptor; Renin–angiotensin system; Pharmacology; Positron emission tomography; In vitro; Internal medicine; Biochemistry; Medicine; Nuclear medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002118561,0.0004431399,0.0004202755,0.0002236342,0.0001853298,0.0002425159,0.0003587941,0.0004611173,0.001422721],"category_scores_gemma":[0.0002428473,0.0001510843,0.0002688525,0.0002539474,0.0002004801,0.0003615666,0.0001677946,0.0004677421,0.0007540126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003245664,"about_ca_system_score_gemma":0.0002858083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007588223,"about_ca_topic_score_gemma":0.001114048,"domain_scores_codex":[0.9998944,0.00002087773,0.000008552577,0.0000220187,0.00002792465,0.00002621067],"domain_scores_gemma":[0.9998887,0.00001645216,0.00002308784,0.00001328345,0.00002750517,0.00003093557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001833299,0.00005882363,0.00008851349,0.0001458059,0.00001771258,0.0002763309,0.00004931594,0.0007037256,0.9921904,0.0005607653,0.000150823,0.005574435],"study_design_scores_gemma":[0.00004529619,0.0005810065,0.0004324599,0.00001580759,0.00002443448,0.0003400114,0.00002330994,0.001295113,0.9896242,0.00008446076,0.007510387,0.00002346408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9490844,0.005383037,0.03709546,0.0001974424,0.00007488766,0.0004133764,0.0009557488,0.0003263767,0.006469199],"genre_scores_gemma":[0.9492865,0.004169559,0.03688969,0.0001259814,0.00005591178,0.0003392841,0.001555782,0.0001043181,0.00747298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422721,"threshold_uncertainty_score":0.00475949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02339089873974195,"score_gpt":0.2693226619138682,"score_spread":0.2459317631741262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}