{"id":"W3016451403","doi":"10.1016/j.eururo.2020.03.021","title":"Immune Signatures Dominate Molecular Subtyping to Predict Response to Neoadjuvant Immunotherapy","year":2020,"lang":"en","type":"letter","venue":"European Urology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Subtyping; Immunotherapy; Immune system; Neoadjuvant therapy; Immunology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005511673,0.0004486899,0.001152325,0.0007417112,0.001372466,0.002858064,0.0007736846,0.01057718,0.002127387],"category_scores_gemma":[0.01791527,0.0004302311,0.0005519876,0.0004953477,0.002342607,0.002195659,0.001002446,0.01331901,0.002390313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002103353,"about_ca_system_score_gemma":0.001483003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002057274,"about_ca_topic_score_gemma":0.005353445,"domain_scores_codex":[0.997201,0.001075406,0.0003075393,0.0002751058,0.0007088277,0.0004321649],"domain_scores_gemma":[0.9879057,0.008702287,0.0004269301,0.0003708916,0.001501434,0.001092796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.001247478,0.0002327931,0.0542687,0.0002643095,0.0001259541,0.01276451,0.0006169587,0.0007252322,0.004729532,0.01280238,0.7026549,0.2095672],"study_design_scores_gemma":[0.000714689,0.001159782,0.03986013,0.0009332363,0.0002433606,0.03826207,0.002431408,0.009757054,0.004424531,0.09510671,0.8068986,0.0002084557],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.01250673,0.007906707,0.001406249,0.9485064,0.01820278,0.00003007276,0.00005580704,0.00006380102,0.01132159],"genre_scores_gemma":[0.1235669,0.004864638,0.001893795,0.7421276,0.1184426,0.00006607936,0.00006478571,0.00007589271,0.008897758],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01057718,"threshold_uncertainty_score":0.02914888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00769869526836274,"score_gpt":0.2191439808445789,"score_spread":0.2114452855762162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}