{"id":"W3016451403","doi":"10.1016/j.eururo.2020.03.021","title":"Immune Signatures Dominate Molecular Subtyping to Predict Response to Neoadjuvant Immunotherapy","year":2020,"lang":"en","type":"letter","venue":"European Urology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Subtyping; Immunotherapy; Immune system; Neoadjuvant therapy; Immunology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.001598228,0.001332114,0.001670226,0.001052697,0.0004953568,0.000115883,0.002603306,0.001365528,0.001491697],"category_scores_gemma":[0.001120068,0.001293078,0.0007050678,0.000655772,0.0004439575,0.00009835243,0.0008601549,0.005092751,0.01275675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001418217,"about_ca_system_score_gemma":0.0002547449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004346798,"about_ca_topic_score_gemma":7.947669e-7,"domain_scores_codex":[0.984372,0.01048343,0.00138599,0.001713254,0.0001845656,0.001860755],"domain_scores_gemma":[0.9958771,0.001322258,0.0004947054,0.001996779,0.0002003423,0.0001088132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01792535,0.00004398511,0.000003415233,0.0000208896,0.0007214483,0.00306282,0.001121283,0.00004247764,0.5615356,0.00001219555,0.4104695,0.005041002],"study_design_scores_gemma":[0.002670849,0.003740944,0.001090118,0.0001033766,0.0001213573,0.0004148436,0.00003614198,0.000001622748,0.04833958,0.0000293525,0.9422425,0.001209318],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.06225666,0.04327977,0.001977076,0.8805695,0.005519579,0.002352804,0.000334845,0.0008948446,0.002814962],"genre_scores_gemma":[0.1038838,0.0003138072,0.000212358,0.8790585,0.00078552,0.0001189905,0.0006509945,0.0006111879,0.01436482],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.531773,"threshold_uncertainty_score":0.999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00769869526836274,"score_gpt":0.2191439808445789,"score_spread":0.2114452855762162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}