{"id":"W3016455540","doi":"10.1128/jb.00776-19","title":"ScmR, a Global Regulator of Gene Expression, Quorum Sensing, pH Homeostasis, and Virulence in <i>Burkholderia thailandensis</i>","year":2020,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Biology; Quorum sensing; Virulence; Regulator; Burkholderia; Burkholderia pseudomallei; Microbiology; Gene; Regulon; Regulation of gene expression; Genetics; Pathogen; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154634,0.0002634472,0.0001460243,0.0001884883,0.0001314717,0.0002357439,0.00007782263,0.000125424,0.0005969663],"category_scores_gemma":[0.0001638209,0.0000590497,0.0001030186,0.000133583,0.0002059799,0.0001452029,0.0001558707,0.0001827285,0.0002264054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000151101,"about_ca_system_score_gemma":0.0001864324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006497357,"about_ca_topic_score_gemma":0.0006659692,"domain_scores_codex":[0.9999167,0.00001760098,0.000005867309,0.00002641867,0.00001727944,0.00001612019],"domain_scores_gemma":[0.9998612,0.00002647557,0.00004680144,0.000008869752,0.00001750104,0.00003906844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001007875,0.000007029587,0.001969299,0.00005209629,0.000002390741,0.00009547095,0.00003084579,0.000122914,0.9958445,0.00007360549,0.00002323072,0.001677821],"study_design_scores_gemma":[0.00002739256,0.0007876622,0.100148,0.00003722401,0.00003248879,0.002037301,0.0003275023,0.003135158,0.8880406,0.0004503946,0.004952036,0.00002416089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899303,0.002687627,0.005190651,0.0001362218,0.000009499201,0.00002430128,0.0006792691,0.0001156246,0.001226572],"genre_scores_gemma":[0.996767,0.0003468716,0.00168336,0.00003118981,0.00000639366,0.00001307348,0.0005499052,0.000007828873,0.0005941792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006497357,"threshold_uncertainty_score":0.001997054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806034223706749,"score_gpt":0.2580823704788774,"score_spread":0.2400220282418099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}