{"id":"W3016481903","doi":"10.1016/j.ejpb.2020.03.015","title":"Gastro-protective protein-silica nanoparticles formulation for oral drug delivery: In vitro release, cytotoxicity and mitochondrial activity","year":2020,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Health and Medical Research Council; Universität Wien; University of Queensland","keywords":"Cytotoxicity; Mesoporous silica; Chemistry; Drug delivery; Nanoparticle; Controlled release; Drug; Biophysics; Drug carrier; In vitro; Pharmacology; Mesoporous material; Biochemistry; Nanotechnology; Organic chemistry; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001407146,0.0002929274,0.0004143861,0.0001268737,0.0001884662,0.0001617541,0.0002524513,0.00004080268,0.00001504493],"category_scores_gemma":[0.000171844,0.0002647954,0.0001043991,0.0002531408,0.0001502779,0.0005394944,0.0001830908,0.0004395153,0.00000869975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008668693,"about_ca_system_score_gemma":0.0001025702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006322784,"about_ca_topic_score_gemma":0.000002412089,"domain_scores_codex":[0.9973586,0.0006898915,0.0006944474,0.0003743547,0.0003685105,0.0005141812],"domain_scores_gemma":[0.9983643,0.0001591924,0.0005265616,0.0001164309,0.0002766727,0.0005567857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006586101,0.0001767524,0.0002371865,0.0001250847,0.00002910391,0.0001036124,0.0006240393,0.0001376693,0.9822137,0.000019831,0.00004133509,0.009705611],"study_design_scores_gemma":[0.006113585,0.0004448459,0.0004324042,0.00005310269,0.0001286671,0.00003713142,0.0001533017,0.02655336,0.9644266,0.00004362293,0.001345371,0.0002680566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955482,0.0005761918,0.001074046,0.001520154,0.0002097062,0.0009193366,0.0001037977,0.00003577334,0.00001282557],"genre_scores_gemma":[0.9925742,0.0001476326,0.006269248,0.0005746956,0.0003739631,0.000008959121,0.000001875395,0.00004498376,0.000004486451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02641569,"threshold_uncertainty_score":0.9999804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04191162574864313,"score_gpt":0.2865835371990199,"score_spread":0.2446719114503768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}