{"id":"W3016496251","doi":"10.2217/pgs-2019-0179","title":"Pharmacoresponse in Genetic Generalized Epilepsy: A Genome-Wide Association Study","year":2020,"lang":"en","type":"article","venue":"Pharmacogenomics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Deutsche Forschungsgemeinschaft; European Commission; National Institute for Health and Care Research","keywords":"Genome-wide association study; Lamotrigine; Genetic association; Single-nucleotide polymorphism; Pharmacogenetics; Candidate gene; SNP; Epilepsy; Levetiracetam; Medicine; Genetics; Biology; Genotype; Gene; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002344776,0.0002456135,0.0002167483,0.00006608505,0.00006665632,0.00003611048,0.0003173047,0.00007567605,0.00009152039],"category_scores_gemma":[0.000128777,0.000286712,0.00009198811,0.0002154901,0.00001793464,0.000004140084,0.0002089212,0.0001512294,0.00007387653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007480499,"about_ca_system_score_gemma":0.0001172762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000014759,"about_ca_topic_score_gemma":0.00002368243,"domain_scores_codex":[0.9982384,0.0002194516,0.0004006438,0.0005575317,0.0001910052,0.0003929553],"domain_scores_gemma":[0.9994212,0.000028765,0.0001336529,0.0001648848,0.00004955654,0.0002018989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004738226,0.0002133656,0.3246884,0.000008037303,0.00008832541,0.00002370362,0.0004356575,0.001745466,0.6705248,3.238919e-7,0.001285478,0.0005126172],"study_design_scores_gemma":[0.008858853,0.0005819256,0.8111925,0.000002476755,0.0001064236,0.000003520365,0.000300783,0.001340746,0.09693396,0.00002216777,0.07985341,0.0008032941],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972117,0.0006743529,0.0001604301,0.0008240929,0.0001736125,0.0007160974,0.00003702777,0.00002063093,0.0001820565],"genre_scores_gemma":[0.9903014,0.001147744,0.000539616,0.00754064,0.0001049936,0.00007766532,0.00007582011,0.00005731672,0.0001547966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5735908,"threshold_uncertainty_score":0.9999585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902765804985087,"score_gpt":0.2675745959255947,"score_spread":0.2485469378757439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}