{"id":"W3016496251","doi":"10.2217/pgs-2019-0179","title":"Pharmacoresponse in Genetic Generalized Epilepsy: A Genome-Wide Association Study","year":2020,"lang":"en","type":"article","venue":"Pharmacogenomics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Deutsche Forschungsgemeinschaft; European Commission; National Institute for Health and Care Research","keywords":"Genome-wide association study; Lamotrigine; Genetic association; Single-nucleotide polymorphism; Pharmacogenetics; Candidate gene; SNP; Epilepsy; Levetiracetam; Medicine; Genetics; Biology; Genotype; Gene; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009683934,0.0005639188,0.0003669901,0.0005643148,0.0003056743,0.0005553036,0.00035456,0.0006030733,0.001969151],"category_scores_gemma":[0.001717131,0.000183882,0.0008927406,0.001147957,0.0004202097,0.0002251507,0.0005527196,0.0004747341,0.0001578776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001503307,"about_ca_system_score_gemma":0.0002474369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002725927,"about_ca_topic_score_gemma":0.003738143,"domain_scores_codex":[0.9993824,0.0002269672,0.00006915332,0.0001974422,0.00007060938,0.00005347206],"domain_scores_gemma":[0.9991075,0.0003179574,0.0003291982,0.0001003521,0.0000574613,0.00008756656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001508149,0.00009312212,0.9779203,0.0001231815,0.002454485,0.001446097,0.0001531643,0.0003240705,0.006556501,0.0003148851,0.0003395901,0.008766455],"study_design_scores_gemma":[0.00008168887,0.0001794104,0.9965472,0.00001875123,0.0007064629,0.0009277335,0.00007611982,0.0004696093,0.0002963549,0.000258562,0.0004304498,0.000007744727],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975684,0.001051463,0.0003629874,0.0001850067,0.00001164708,0.000007982727,0.0004255225,0.00001316065,0.0003737812],"genre_scores_gemma":[0.9989078,0.0002528865,0.0004003245,0.00005133356,0.00001368293,0.000004635224,0.0002641169,0.000005210717,0.00009998425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002725927,"threshold_uncertainty_score":0.006587505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902765804985087,"score_gpt":0.2675745959255947,"score_spread":0.2485469378757439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}