{"id":"W3016496701","doi":"10.1080/20013078.2020.1816641","title":"Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration","year":2020,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"National Institute of Mental Health; National Institute of Allergy and Infectious Diseases; Helse Sør-Øst RHF; Foundation for the National Institutes of Health; Cancer Research UK; Norges Forskningsråd; Javna Agencija za Raziskovalno Dejavnost RS; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; National Cancer Institute; National Department of Health; National Institute on Drug Abuse; Prostate Cancer Foundation; European Metrology Programme for Innovation and Research; Biotechnology and Biological Sciences Research Council; Michael J. Fox Foundation for Parkinson's Research","keywords":"Extracellular vesicles; Extracellular vesicle; Standardization; Epitope; Characterization (materials science); Epitope mapping; Focus (optics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001236863,0.000360264,0.0005153671,0.00004723652,0.0001963793,0.000180537,0.0004270748,0.0002695744,0.00004662147],"category_scores_gemma":[0.001806383,0.0003581704,0.0001912521,0.0001356407,0.0001921457,0.00008929731,0.0001286886,0.0002835201,0.000006563042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006436253,"about_ca_system_score_gemma":0.0003873907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007640446,"about_ca_topic_score_gemma":0.000002004483,"domain_scores_codex":[0.9971974,0.0002370803,0.001057778,0.0005264487,0.0005311265,0.0004501456],"domain_scores_gemma":[0.9975281,0.0001365603,0.001018307,0.0003130884,0.0005788641,0.0004250716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001244382,0.0001111023,0.0008029715,0.0001636548,0.0001435305,0.0000671388,0.0002814155,0.0001243874,0.9900987,0.00110855,0.000360424,0.005493747],"study_design_scores_gemma":[0.002109037,0.0008246484,0.002102902,0.0001322624,0.0001469616,0.0001099946,0.000478257,0.0002221501,0.9770622,0.0007010307,0.01567271,0.0004378684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454489,0.03036895,0.02267482,0.0005982922,0.0002322847,0.000420277,0.00006575685,0.00002018161,0.0001704848],"genre_scores_gemma":[0.9870784,0.0009193343,0.01095839,0.0001867395,0.0006496386,0.00001743403,0.00003096901,0.00007578322,0.00008336125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0416294,"threshold_uncertainty_score":0.999887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0250947225437344,"score_gpt":0.2604225498593821,"score_spread":0.2353278273156477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}