{"id":"W3016496701","doi":"10.1080/20013078.2020.1816641","title":"Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration","year":2020,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"National Institute of Mental Health; National Institute of Allergy and Infectious Diseases; Helse Sør-Øst RHF; Foundation for the National Institutes of Health; Cancer Research UK; Norges Forskningsråd; Javna Agencija za Raziskovalno Dejavnost RS; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; National Cancer Institute; National Department of Health; National Institute on Drug Abuse; Prostate Cancer Foundation; European Metrology Programme for Innovation and Research; Biotechnology and Biological Sciences Research Council; Michael J. Fox Foundation for Parkinson's Research","keywords":"Extracellular vesicles; Extracellular vesicle; Standardization; Epitope; Characterization (materials science); Epitope mapping; Focus (optics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02910512,0.001925866,0.001440717,0.005374566,0.001381171,0.003936865,0.003392184,0.00433482,0.001987422],"category_scores_gemma":[0.02528286,0.001030999,0.00126893,0.001912601,0.002368384,0.004253088,0.003746483,0.003662201,0.003421829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001909869,"about_ca_system_score_gemma":0.002617408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001250746,"about_ca_topic_score_gemma":0.002015981,"domain_scores_codex":[0.9846118,0.005335473,0.001213305,0.002074654,0.006333645,0.0004310757],"domain_scores_gemma":[0.9839377,0.0052425,0.001934432,0.001951798,0.006647985,0.0002855956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000223597,0.0001773211,0.002496667,0.001938685,0.00006936556,0.0001691339,0.0005733229,0.00190142,0.8759219,0.02107386,0.003781238,0.09167358],"study_design_scores_gemma":[0.00002270781,0.0004288908,0.002461273,0.0008680862,0.00009771662,0.0005529744,0.0003956361,0.007071575,0.9104207,0.007929417,0.06960009,0.0001510435],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03867866,0.02328302,0.9177322,0.001995064,0.001575741,0.0008532286,0.001137097,0.00174503,0.01299998],"genre_scores_gemma":[0.07467183,0.01185774,0.9015153,0.001236421,0.0002851546,0.001864673,0.00247275,0.0006874707,0.005408609],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.02910512,"threshold_uncertainty_score":0.1539244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0250947225437344,"score_gpt":0.2604225498593821,"score_spread":0.2353278273156477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}