{"id":"W3016497088","doi":"10.7554/elife.47333","title":"Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University Health Network; University of Toronto; Princess Margaret Cancer Centre; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Ontario Genomics; Ontario Ministry of Research, Innovation and Science; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Canadian Institutes of Health Research; Wellcome; Merck KGaA; Wellcome Trust; Pfizer","keywords":"Biology; Telomere; Embryonic stem cell; Epigenetics; Chromatin; Telomerase; Cellular differentiation; Telomerase reverse transcriptase; Cell biology; Stem cell; DNA methylation; Epigenome; Genome instability; DNA demethylation; Genetics; Gene; Gene expression; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001488355,0.0004262583,0.0001859999,0.0002889357,0.000103505,0.0002029597,0.0001630775,0.0002331519,0.0007735821],"category_scores_gemma":[0.0001023363,0.00015212,0.0002330716,0.0001236726,0.0002109194,0.0001173286,0.0002460808,0.0004464045,0.0002079537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001679576,"about_ca_system_score_gemma":0.0001517548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003629024,"about_ca_topic_score_gemma":0.0006994995,"domain_scores_codex":[0.9998631,0.00002382677,0.0000197888,0.00002875486,0.00002834504,0.00003605918],"domain_scores_gemma":[0.9998689,0.0000140528,0.00005768877,0.0000223749,0.00000706927,0.00003001792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007528524,0.00001433068,0.0004462545,0.00001400996,0.000007619806,0.00008492297,0.000006979629,0.00007169935,0.9983011,0.00008968772,0.00002086494,0.0008672164],"study_design_scores_gemma":[0.000008430476,0.0002366855,0.01040074,0.000004023972,0.00002064013,0.0004221983,0.00002057778,0.0007031054,0.9870681,0.00008368177,0.001027967,0.000003851429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957176,0.001088853,0.002020122,0.00005352924,0.00002079912,0.00001047854,0.0002691364,0.0001015448,0.0007180109],"genre_scores_gemma":[0.9974881,0.0005042752,0.0005112896,0.00002362259,0.000005012469,0.000009238078,0.0002107264,0.00001190799,0.001235822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007735821,"threshold_uncertainty_score":0.002587855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405063749030458,"score_gpt":0.2319901161394438,"score_spread":0.2179394786491393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}