{"id":"W3016525618","doi":"10.1016/j.ymthe.2020.04.013","title":"Check and Checkmate: Battling Cancer with Multiplex Immunotherapy","year":2020,"lang":"en","type":"letter","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Oncolytic virus; Cancer; Cancer immunotherapy; Immunotherapy; Tumor microenvironment; Cancer immunology; Medicine; Immune system; Immune checkpoint; Cancer research; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001641585,0.0007726467,0.001093336,0.0002409968,0.000127819,0.0001487499,0.000346339,0.0006904492,0.003720522],"category_scores_gemma":[0.00001569935,0.0006013968,0.0002919183,0.0004034677,0.0003130614,0.00005736436,0.00006279924,0.002728033,0.00005111222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002144639,"about_ca_system_score_gemma":0.0004130166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003510853,"about_ca_topic_score_gemma":0.000006435309,"domain_scores_codex":[0.9964758,0.0001835931,0.0004010366,0.001030394,0.00109394,0.0008152232],"domain_scores_gemma":[0.9983909,0.00008180575,0.000179961,0.0009258761,0.0002074432,0.0002140397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002887625,0.0000836946,0.0005670359,0.0003935294,0.002385626,0.005594362,0.0007922213,0.000007026036,0.8076742,0.000002938923,0.1045477,0.075064],"study_design_scores_gemma":[0.006658936,0.000840468,0.0002773433,0.0003065522,0.00008005225,0.000186691,0.00002682008,0.0001558278,0.09037638,0.00003466684,0.9003987,0.0006575804],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.09497844,0.03469006,0.0005896268,0.8642935,0.0002552717,0.003113861,0.00006855889,0.0003673481,0.001643355],"genre_scores_gemma":[0.005338464,0.02105963,0.001328626,0.9565264,0.002554499,0.0005332955,0.0003805952,0.0007360688,0.01154244],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.795851,"threshold_uncertainty_score":0.9996437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190717010889309,"score_gpt":0.3053762519500328,"score_spread":0.2734690818411397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}