{"id":"W3016549252","doi":"10.1101/2020.04.15.043679","title":"Complexity of the eukaryotic dolichol-linked oligosaccharide scramblase suggested by activity correlation profiling mass spectrometry","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eidgenössische Technische Hochschule Zürich; University at Buffalo; University of Toronto; University of Bern; State University of New York; Weill Cornell Medical College; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Dolichol; Phospholipid scramblase; Flippase; Biochemistry; Endoplasmic reticulum; Chemistry; Glycosylation; Biology; Cell biology; Phospholipid; Membrane; Phosphatidylserine; Biosynthesis; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002271649,0.0004150601,0.0001640036,0.0004359935,0.0001386271,0.000519646,0.0002525965,0.0003477093,0.0006255941],"category_scores_gemma":[0.0004120399,0.0001489177,0.0002826047,0.0002458795,0.000227751,0.0003464582,0.0001845923,0.000410125,0.0003373427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002904908,"about_ca_system_score_gemma":0.0002075551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004764455,"about_ca_topic_score_gemma":0.0003901591,"domain_scores_codex":[0.9998862,0.00001186275,0.000007438203,0.00003709113,0.00003616405,0.00002138087],"domain_scores_gemma":[0.9997906,0.0000427084,0.00008071563,0.00002124592,0.00003628073,0.00002851991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008240843,0.000007916125,0.0008192405,0.0000242199,0.000008989139,0.0001299218,0.00001146715,0.0001612676,0.9962896,0.0003387268,0.00004306413,0.00208316],"study_design_scores_gemma":[0.000007460122,0.0001426596,0.01216638,0.00001533453,0.00002900656,0.0007946009,0.00003521741,0.007554146,0.9755169,0.0003985378,0.003326521,0.00001329581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578102,0.002034146,0.03619655,0.0002460898,0.00002719904,0.00008401274,0.0007636754,0.0003023584,0.002535796],"genre_scores_gemma":[0.9759942,0.0008747432,0.02064328,0.0001253143,0.00001283132,0.00002804078,0.001180026,0.00003433021,0.001107141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006255941,"threshold_uncertainty_score":0.002107739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02603079029415731,"score_gpt":0.2563696687128384,"score_spread":0.2303388784186811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}