{"id":"W3016590474","doi":"10.1080/14756366.2020.1751620","title":"Preparation, carbonic anhydrase enzyme inhibition and antioxidant activity of novel 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives incorporating mono or dipeptide moiety","year":2020,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dell’Istruzione, dell’Università e della Ricerca; Università degli Studi di Firenze; Canadian Thoracic Society","keywords":"Chemistry; Dipeptide; Antioxidant; DPPH; Carbonic anhydrase; Moiety; Carbonic Anhydrase I; Enzyme; Stereochemistry; Peptide; Medicinal chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008583647,0.0002163794,0.000183365,0.00008681796,0.00007083036,0.000118794,0.0002151009,0.0002194291,0.0005426022],"category_scores_gemma":[0.0000739384,0.00008594605,0.0001336612,0.00007880541,0.0001122342,0.0001144471,0.00006338556,0.0002665531,0.0001605884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399595,"about_ca_system_score_gemma":0.0001189231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002445558,"about_ca_topic_score_gemma":0.0004503416,"domain_scores_codex":[0.9999582,0.000004973794,0.000004922289,0.00001131007,0.00001256879,0.000008130061],"domain_scores_gemma":[0.9999514,0.000006448069,0.00001545024,0.000004407555,0.000008523432,0.00001367386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003208142,0.000009728242,0.00002129101,0.00003053623,0.000002193821,0.00003106166,0.00000421215,0.0000449551,0.999092,0.0000240735,0.00001101614,0.000696905],"study_design_scores_gemma":[0.00001894155,0.0004525565,0.0007280913,0.000002835082,0.00001139575,0.0001616217,0.000003794103,0.0002140428,0.9969423,0.00001192737,0.001448706,0.000003737355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901148,0.003873861,0.004357408,0.00007515933,0.00003422345,0.00005286547,0.0002603589,0.00004934667,0.001182088],"genre_scores_gemma":[0.9923927,0.001380147,0.004192567,0.00003607084,0.00001198412,0.00002409583,0.0003085804,0.00000781582,0.001646101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005426022,"threshold_uncertainty_score":0.0018152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415439762431237,"score_gpt":0.2705194995020288,"score_spread":0.2463651018777164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}