{"id":"W3016674570","doi":"10.1080/23723556.2020.1740541","title":"The plot thickens: OTULIN regulation in cell death","year":2020,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Necroptosis; Deubiquitinating enzyme; RIPK1; Phosphorylation; Biology; Ubiquitin; Serine; Dual-specificity phosphatase; Programmed cell death; Cell biology; Phosphatase; Kinase; Protein phosphatase 2; Threonine; Molecular biology; Genetics; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001800397,0.0004444702,0.0002216616,0.0006421537,0.0006723144,0.001064851,0.0002949802,0.0004776257,0.003091631],"category_scores_gemma":[0.000161134,0.0001682708,0.0002003137,0.0003020779,0.0006369135,0.000767811,0.0007151585,0.0005695704,0.0007198601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007968966,"about_ca_system_score_gemma":0.0002233993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001088387,"about_ca_topic_score_gemma":0.001481859,"domain_scores_codex":[0.9998518,0.00001871812,0.000006533489,0.00004057643,0.00004356467,0.00003871128],"domain_scores_gemma":[0.9998412,0.0000114284,0.00006293776,0.000009929693,0.00001961571,0.00005475068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002445798,0.00002206193,0.00113161,0.00009282715,0.0000148902,0.0005306014,0.00005466507,0.0002822955,0.9828189,0.003237701,0.0003450974,0.01122474],"study_design_scores_gemma":[0.00003667723,0.0002730312,0.03319558,0.00002905777,0.00003849438,0.00186308,0.0002066277,0.00278319,0.9282736,0.001900916,0.03137358,0.00002617167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9427121,0.03007554,0.009761918,0.0007058698,0.000174225,0.00004036817,0.0003506583,0.0002750969,0.01590412],"genre_scores_gemma":[0.98251,0.003324235,0.001530587,0.0001414883,0.00003275912,0.00001127663,0.000146564,0.00003397244,0.01226908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003091631,"threshold_uncertainty_score":0.01034254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203844839817062,"score_gpt":0.2498942447612539,"score_spread":0.2295097607795477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}