{"id":"W3016674570","doi":"10.1080/23723556.2020.1740541","title":"The plot thickens: OTULIN regulation in cell death","year":2020,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Necroptosis; Deubiquitinating enzyme; RIPK1; Phosphorylation; Biology; Ubiquitin; Serine; Dual-specificity phosphatase; Programmed cell death; Cell biology; Phosphatase; Kinase; Protein phosphatase 2; Threonine; Molecular biology; Genetics; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004557118,0.0002253716,0.0002278039,0.00003513752,0.0001411041,0.00003443292,0.0004029695,0.0003621082,0.00004073992],"category_scores_gemma":[0.0001677671,0.0001945681,0.0001388042,0.0001734143,0.0001100761,0.000003911752,0.0002133007,0.0003057972,0.0001122319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004476062,"about_ca_system_score_gemma":0.0002099815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002203572,"about_ca_topic_score_gemma":0.00003909314,"domain_scores_codex":[0.998036,0.0004469774,0.0003648638,0.0005203463,0.0001885172,0.0004432415],"domain_scores_gemma":[0.9991754,0.00003995468,0.0001357258,0.000422869,0.00007169459,0.0001543385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001679785,0.00006599654,0.0003975874,0.00001755191,0.00002007587,0.00009608977,0.0001818255,0.0002393577,0.9948484,0.0008998078,0.0006867563,0.002378581],"study_design_scores_gemma":[0.0007934585,0.000602756,0.000196004,0.000004832186,0.00001463245,0.000008703895,0.00008059826,0.0006007687,0.7723004,0.0004193692,0.2247873,0.0001911127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597484,0.004531405,0.0147991,0.004605265,0.0002065891,0.0006964866,0.000009707388,0.00004360721,0.01535948],"genre_scores_gemma":[0.9947742,0.0002080126,0.001393722,0.00277698,0.0002387352,0.00007384756,0.0001264964,0.00004807611,0.0003599246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2241006,"threshold_uncertainty_score":0.7934257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203844839817062,"score_gpt":0.2498942447612539,"score_spread":0.2295097607795477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}