{"id":"W3016676170","doi":"10.1113/jp278707","title":"Coupling structure with function in acid‐sensing ion channels: challenges in pursuit of proton sensors","year":2020,"lang":"en","type":"review","venue":"The Journal of Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Brain and Behavior Research Foundation; Canada Research Chairs; National Alliance for Research on Schizophrenia and Depression","keywords":"Proton; Coupling (piping); Ion; Acid-sensing ion channel; Function (biology); Physics; Chemistry; Biophysics; Ion channel; Biological system; Chemical physics; Materials science; Biology; Biochemistry; Cell biology; Nuclear physics; Quantum mechanics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001063364,0.0009036211,0.001532969,0.001326405,0.0003579616,0.001371665,0.001278433,0.002205436,0.00268623],"category_scores_gemma":[0.00127089,0.000407985,0.0005102665,0.001553629,0.001119015,0.003471049,0.001183141,0.003585996,0.002520759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001020565,"about_ca_system_score_gemma":0.001396662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007381901,"about_ca_topic_score_gemma":0.001007398,"domain_scores_codex":[0.9997323,0.00005067507,0.00003451985,0.0000458102,0.0001041549,0.00003244293],"domain_scores_gemma":[0.9994366,0.0003008427,0.00004050585,0.00002170364,0.0001381966,0.00006211657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001073984,0.00007604126,0.0001417021,0.01659844,0.00007123292,0.0002695748,0.0001502328,0.001020792,0.003822911,0.03255807,0.05321736,0.8919662],"study_design_scores_gemma":[0.0000109414,0.00007592428,0.000232542,0.001967422,0.00003680963,0.0004756674,0.00005931157,0.000150581,0.0004675423,0.008333662,0.9881706,0.0000190659],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008698015,0.9978757,0.0002552384,0.0006903571,0.0004232439,0.000002223013,0.00000881603,0.000009423107,0.0006479848],"genre_scores_gemma":[0.0005679908,0.9976592,0.0002862189,0.0005041576,0.000354999,0.000005491799,0.00001772093,0.000003327116,0.0006009233],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00268623,"threshold_uncertainty_score":0.008986354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03461994805671902,"score_gpt":0.2684586047329223,"score_spread":0.2338386566762033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}