{"id":"W3016691518","doi":"10.1096/fasebj.2020.34.s1.08716","title":"Phosphorylated Connexin 43 is Associated with Increased Susceptibility for Atrial Fibrillation in Mice Treated with a Single High Dose of Ibrutinib but not Acalabrutinib","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Ibrutinib; Connexin; Atrial fibrillation; Pharmacology; Medicine; Bruton's tyrosine kinase; Internal medicine; Chemistry; Tyrosine kinase; Gap junction; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003002036,0.0008085626,0.0007986371,0.001293971,0.0004560874,0.0004479128,0.0002930379,0.001142386,0.00403579],"category_scores_gemma":[0.0001642717,0.0005262914,0.0008073497,0.0005036346,0.0007280532,0.0004834713,0.0002890859,0.002771855,0.0007669631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003899689,"about_ca_system_score_gemma":0.0001990527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005816685,"about_ca_topic_score_gemma":0.0009305648,"domain_scores_codex":[0.9995221,0.00004747396,0.00004574705,0.0001465375,0.00008324965,0.0001548867],"domain_scores_gemma":[0.9994177,0.00003735533,0.0001828628,0.00003319845,0.00002742604,0.0003015022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001391968,0.0002723963,0.0006048756,0.00005744298,0.00002446029,0.0002267786,0.00005612259,0.00004837419,0.9964495,0.0000732448,0.0001594064,0.0006354593],"study_design_scores_gemma":[0.0006364422,0.009696087,0.1336055,0.0000937463,0.0002790773,0.004084271,0.0005894818,0.00350866,0.842365,0.0004924199,0.004569292,0.00007996819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928578,0.001440667,0.001509908,0.0004496694,0.0001696767,0.00006943542,0.001742478,0.000177879,0.001582442],"genre_scores_gemma":[0.9895101,0.001229457,0.001365238,0.0002883852,0.00006944784,0.0002836934,0.001375993,0.00006487731,0.005812764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00403579,"threshold_uncertainty_score":0.01350111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03837297810425275,"score_gpt":0.2821977376275045,"score_spread":0.2438247595232517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}