{"id":"W3016707205","doi":"10.1096/fasebj.2020.34.s1.03392","title":"Inhibition of Sirtuin‐1 Ameliorates Vascular Remodeling and Hypertension in SHR","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Endocrinology; Internal medicine; Sirtuin 1; Downregulation and upregulation; Vascular smooth muscle; Pathogenesis; NADPH oxidase; Enos; Medicine; Angiotensin II; Nitric oxide synthase; Superoxide; Nitric oxide; Blood pressure; Chemistry; Oxidative stress; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819626,0.0005762895,0.0006724964,0.0003021628,0.0001778445,0.0001611868,0.0002124376,0.0002490974,0.001438897],"category_scores_gemma":[0.00008207696,0.000228359,0.00040195,0.0001208382,0.0001951364,0.0002504113,0.0002211105,0.0008292351,0.0002281862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001259502,"about_ca_system_score_gemma":0.0001999717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006826909,"about_ca_topic_score_gemma":0.0012508,"domain_scores_codex":[0.9999197,0.00001461931,0.000009862001,0.0000116691,0.00001750753,0.00002661395],"domain_scores_gemma":[0.9999123,0.000005170591,0.00002724049,0.000007912215,0.00001068367,0.00003657681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002890704,0.0008703101,0.0007590136,0.0002255646,0.00007327837,0.0001263348,0.00005437734,0.0001240847,0.983514,0.00008903475,0.000225493,0.01104783],"study_design_scores_gemma":[0.001590708,0.0361014,0.07016389,0.00009017467,0.0006960251,0.0007570341,0.0002779218,0.005098665,0.8772698,0.0003757335,0.007532127,0.00004644088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945213,0.002806255,0.001242441,0.000161154,0.00009132733,0.00003797922,0.0002016591,0.0002041444,0.0007337297],"genre_scores_gemma":[0.9934622,0.002500817,0.001268044,0.0001587511,0.00005036075,0.00005169924,0.000391959,0.00002165155,0.002094581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001438897,"threshold_uncertainty_score":0.004813552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03099822295465458,"score_gpt":0.2468309059679175,"score_spread":0.2158326830132629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}