{"id":"W3016724706","doi":"10.3390/cancers12040993","title":"Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Medical Research Council; Canadian Institutes of Health Research; British Heart Foundation; CancerCare Manitoba Foundation; Università Degli Studi di Modena e Reggio Emila","keywords":"Chromosome instability; Genome instability; Chromosome segregation; Spindle checkpoint; Mad2; Mitosis; Biology; Cell biology; Chromosome; Cancer research; Genetics; DNA damage; Gene; DNA; Kinetochore","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006681126,0.0002605332,0.0001577864,0.0002679302,0.0001354336,0.0001859702,0.0001351493,0.0002324903,0.001072479],"category_scores_gemma":[0.00007830792,0.0001102139,0.0001667214,0.0002524499,0.0001563883,0.0001250475,0.0001569562,0.0003547387,0.0002431825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751697,"about_ca_system_score_gemma":0.0001576559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007231333,"about_ca_topic_score_gemma":0.001012749,"domain_scores_codex":[0.9999174,0.00001020374,0.0000116872,0.00001703269,0.00002770295,0.00001600524],"domain_scores_gemma":[0.9999145,0.00001789188,0.00002463677,0.00001088337,0.000005344848,0.0000267034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002693996,0.000006703969,0.00007557949,0.000009520267,0.000002743453,0.00003079952,0.000003760951,0.00002098775,0.9995466,0.00002870267,0.000013116,0.0002345935],"study_design_scores_gemma":[0.000005327523,0.0001217815,0.002867307,0.00000181896,0.00000780884,0.0002355062,0.00001076198,0.0004154135,0.9951611,0.0000231365,0.001148429,0.000001624629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956968,0.0009501959,0.001722641,0.0000711785,0.00001576754,0.00001999096,0.0003684554,0.00009619381,0.001058817],"genre_scores_gemma":[0.9951533,0.0005181727,0.001095912,0.00002339944,0.000003580729,0.00002753838,0.0006191038,0.00001555436,0.002543426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001072479,"threshold_uncertainty_score":0.003587782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341154155107279,"score_gpt":0.2465348911946795,"score_spread":0.2331233496436067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}