{"id":"W3016732475","doi":"10.1128/mbio.00290-20","title":"The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Government of Canada","keywords":"Proteostasis; Proteasome; Biology; Candida albicans; Virulence; Morphogenesis; Cell biology; Corpus albicans; Hsp90; Regulator; Microbiology; Heat shock protein; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002349391,0.0004116104,0.0002607315,0.0003731606,0.0003842009,0.001080187,0.0002852682,0.0003628064,0.001490797],"category_scores_gemma":[0.000205714,0.0001800268,0.0003142947,0.0001937692,0.0003773887,0.0005570746,0.0004664837,0.0006708989,0.0006636313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004973711,"about_ca_system_score_gemma":0.0005017613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007047364,"about_ca_topic_score_gemma":0.001028082,"domain_scores_codex":[0.9997683,0.0000321648,0.00001594038,0.00005314713,0.0000557153,0.00007478768],"domain_scores_gemma":[0.9998312,0.00001070054,0.0000543411,0.00001553348,0.00003099152,0.00005724892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000220899,0.00009123224,0.002302383,0.0001634559,0.00004364778,0.0003582114,0.00004517293,0.0005149937,0.9753066,0.002507227,0.000978759,0.01746742],"study_design_scores_gemma":[0.0001192909,0.0008206113,0.1199562,0.0001276777,0.0001381964,0.003067019,0.0004172337,0.01521085,0.8198303,0.007223163,0.03300578,0.00008364991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9112417,0.04003048,0.01980758,0.002571846,0.0003582474,0.00009966038,0.0008308664,0.000839,0.02422053],"genre_scores_gemma":[0.9920194,0.004280725,0.001525391,0.0001231034,0.00004605677,0.00001269186,0.0001668086,0.00001353266,0.001812422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001490797,"threshold_uncertainty_score":0.00498724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02091199787032545,"score_gpt":0.2213459098249609,"score_spread":0.2004339119546354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}