{"id":"W3016736024","doi":"10.1101/2020.04.20.049957","title":"<i>Tmed2</i> regulates Smoothened trafficking and Hedgehog signalling","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; McGill University Health Centre; Eidgenössische Technische Hochschule Zürich; McGill University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Smoothened; Cell biology; Hedgehog signaling pathway; Hedgehog; Embryonic stem cell; Biology; Golgi apparatus; Chemistry; Signal transduction; Biochemistry; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006321503,0.0002352118,0.0001351649,0.0001502906,0.0001458015,0.0003323602,0.0001404454,0.0001913267,0.001756865],"category_scores_gemma":[0.00006168713,0.0001158349,0.0001731447,0.00009932354,0.0001538058,0.0001446293,0.0002066868,0.0002661219,0.0006661437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000348094,"about_ca_system_score_gemma":0.0001080009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006763893,"about_ca_topic_score_gemma":0.0009176216,"domain_scores_codex":[0.9999326,0.000006891458,0.000004764146,0.00001739323,0.000020626,0.00001763461],"domain_scores_gemma":[0.9999658,0.000004456572,0.000008570367,0.000003794252,0.000005716466,0.00001163811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006456095,0.000005234174,0.0003336949,0.00001384238,0.000002492846,0.00006703763,0.000003574084,0.00006339253,0.998719,0.0001088571,0.00007876277,0.0005396357],"study_design_scores_gemma":[0.000009174379,0.00003391662,0.007359546,0.000002747457,0.000005441791,0.0002620135,0.00001566467,0.001189189,0.9885811,0.00005757379,0.002480719,0.000002821135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890514,0.001058329,0.003478708,0.0001739146,0.00003967648,0.00001294565,0.001343414,0.0001434189,0.004698092],"genre_scores_gemma":[0.9886668,0.0003438568,0.001997606,0.00006926356,0.000006640515,0.00001017473,0.001934175,0.0000469383,0.006924597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001756865,"threshold_uncertainty_score":0.005877316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01700686560379465,"score_gpt":0.2176306396900429,"score_spread":0.2006237740862482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}