{"id":"W3016736024","doi":"10.1101/2020.04.20.049957","title":"<i>Tmed2</i> regulates Smoothened trafficking and Hedgehog signalling","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; McGill University Health Centre; Eidgenössische Technische Hochschule Zürich; McGill University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Smoothened; Cell biology; Hedgehog signaling pathway; Hedgehog; Embryonic stem cell; Biology; Golgi apparatus; Chemistry; Signal transduction; Biochemistry; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004951991,0.0007984244,0.0007390854,0.0001313228,0.0002708286,0.0002197211,0.0005671383,0.00076292,0.000007756715],"category_scores_gemma":[0.0003804571,0.0008784083,0.0002256565,0.0002382633,0.0002653152,0.000008942707,0.001081089,0.0006184315,0.00001729768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000604402,"about_ca_system_score_gemma":0.0003777812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001298752,"about_ca_topic_score_gemma":0.000002694266,"domain_scores_codex":[0.9965767,0.0001694338,0.000604341,0.001657606,0.0003259622,0.0006659905],"domain_scores_gemma":[0.9979407,0.000050736,0.0003849451,0.0009294896,0.0003287513,0.0003653716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005541819,0.00005001015,0.00125361,0.000413181,0.0003461258,0.00004132231,0.00003105995,0.0002817268,0.9971049,0.00007207638,0.0003440593,0.000006532112],"study_design_scores_gemma":[0.0005749634,0.0001461651,0.005102875,0.0003953179,0.0001664123,5.111278e-8,0.000009847532,0.000399503,0.9840705,0.000005201932,0.00802899,0.001100192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849219,0.009840717,0.003082298,0.0004363613,0.00060115,0.0006698539,0.0001460538,0.000286211,0.00001546549],"genre_scores_gemma":[0.9924017,0.001001726,0.004461222,0.0005638351,0.001198043,0.0001369509,0.000002111672,0.0002275248,0.000006859054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0130344,"threshold_uncertainty_score":0.9993666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01700686560379465,"score_gpt":0.2176306396900429,"score_spread":0.2006237740862482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}