{"id":"W3016810711","doi":"10.1126/sciadv.aaz7602","title":"Sperm DNA damage causes genomic instability in early embryonic development","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Biology; Genome instability; Sperm; DNA damage; Chromothripsis; Genetics; Zygote; Blastomere; Embryo; DNA fragmentation; Embryogenesis; DNA; Programmed cell death; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005988208,0.00009360398,0.0001832874,0.00005629333,0.0001224815,0.00001111202,0.0002098909,0.00002939023,0.00003812161],"category_scores_gemma":[0.000651617,0.00007163572,0.00002139089,0.000565346,0.001017695,0.0004158169,0.00009529752,0.0001467136,0.00006428276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00013036,"about_ca_system_score_gemma":0.0005279019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009301797,"about_ca_topic_score_gemma":0.00005889688,"domain_scores_codex":[0.998711,0.00002955925,0.0001910181,0.0006074692,0.0001855832,0.0002754084],"domain_scores_gemma":[0.999473,0.00002433375,0.00004336713,0.0002568901,0.00006892212,0.0001334272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003106836,0.00005317051,0.7465646,0.00002898312,0.000002441807,0.000009301662,0.00179245,0.000006416417,0.245387,0.00002235236,0.000001711302,0.005820871],"study_design_scores_gemma":[0.0002154859,0.0001071575,0.8934349,0.0000105637,0.000002320472,0.00000209527,0.0002638687,0.0000071201,0.1016516,0.0001138007,0.004117868,0.00007321846],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968466,0.0007151384,0.00002378859,0.001069952,0.0001388121,0.0002503524,0.000001308144,0.00003366933,0.0009204174],"genre_scores_gemma":[0.9983096,0.00001220824,0.00109505,0.0004779497,0.00005039142,0.000009318876,0.000001079322,0.000003114409,0.00004131508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1468703,"threshold_uncertainty_score":0.3749739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0341026421301234,"score_gpt":0.3043598349656637,"score_spread":0.2702571928355403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}