{"id":"W3016810711","doi":"10.1126/sciadv.aaz7602","title":"Sperm DNA damage causes genomic instability in early embryonic development","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Biology; Genome instability; Sperm; DNA damage; Chromothripsis; Genetics; Zygote; Blastomere; Embryo; DNA fragmentation; Embryogenesis; DNA; Programmed cell death; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433197,0.0001735124,0.0002035457,0.0003423075,0.0001593393,0.0001814037,0.00009931104,0.000280708,0.0007906677],"category_scores_gemma":[0.0002831846,0.0001506404,0.0001152319,0.0002729045,0.0002027376,0.0001132873,0.0001795826,0.0002054382,0.0001669319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001261554,"about_ca_system_score_gemma":0.00009840896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004999225,"about_ca_topic_score_gemma":0.0007770661,"domain_scores_codex":[0.9998552,0.0000297528,0.0000141757,0.00004189551,0.00004517397,0.00001384192],"domain_scores_gemma":[0.999842,0.00003211558,0.00008047183,0.00001339302,0.0000187211,0.00001321105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001004642,0.000007074391,0.01677249,0.00009958311,0.00003323617,0.000560353,0.00006988082,0.000180931,0.9752421,0.0001038685,0.00004424388,0.006785819],"study_design_scores_gemma":[0.00001206167,0.0003554107,0.5042371,0.00003798084,0.000133551,0.008030083,0.0001354966,0.0007365569,0.4805216,0.0003805105,0.005403288,0.00001639019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880742,0.0072968,0.003309329,0.00005740992,0.000008564669,0.00001041374,0.0002417244,0.00003676443,0.0009646691],"genre_scores_gemma":[0.9963825,0.001779878,0.00108044,0.0000426601,0.000004993589,0.00000443083,0.0002098951,0.000007359994,0.0004879281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007906677,"threshold_uncertainty_score":0.002645016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0341026421301234,"score_gpt":0.3043598349656637,"score_spread":0.2702571928355403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}