{"id":"W3016827654","doi":"10.1021/acs.jproteome.0c00031","title":"Dried Blood Spot-Based Metabolomic Profiling in Adults with Cystic Fibrosis","year":2020,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Cystic fibrosis; Metabolomics; Cystic fibrosis transmembrane conductance regulator; Newborn screening; Medicine; Metabolome; Internal medicine; Gastroenterology; Endocrinology; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002898605,0.0001992609,0.0007215375,0.0009154388,0.00009653044,0.00007619816,0.0004121867,0.0001020007,0.000167274],"category_scores_gemma":[0.006011302,0.0001393888,0.0001395292,0.001986707,0.0003107387,0.0002774298,0.0001008059,0.002067124,0.00003989064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002014099,"about_ca_system_score_gemma":0.001849055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003628378,"about_ca_topic_score_gemma":0.000009964426,"domain_scores_codex":[0.9948228,0.0005005073,0.0007732249,0.0003670483,0.002701258,0.000835169],"domain_scores_gemma":[0.9966328,0.0007259684,0.0002395967,0.0002931922,0.001347177,0.0007612494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04478697,0.0006394492,0.01773672,0.002776501,0.0001697374,0.002628029,0.0005106037,0.0004072796,0.928403,0.00004959841,0.000188363,0.001703727],"study_design_scores_gemma":[0.03190461,0.02559568,0.03554898,0.007315812,0.0001695332,0.0006597621,0.001687115,0.008726539,0.8863505,0.0002732495,0.001328958,0.0004393026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885514,0.001632211,0.0009951646,0.006577155,0.00002479052,0.001972744,0.00001265507,0.0000210316,0.0002127833],"genre_scores_gemma":[0.9192001,0.0000783975,0.08014261,0.00006666084,0.0003172124,0.00008831469,0.000005413924,0.00004746276,0.00005380701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07914745,"threshold_uncertainty_score":0.8980742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04219811614378541,"score_gpt":0.3541968206702271,"score_spread":0.3119987045264416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}