{"id":"W3016844795","doi":"10.3747/co.27.5283","title":"Chimeric Antigen Receptor T Cell Therapy Comes to Clinical Practice","year":2020,"lang":"en","type":"review","venue":"Current Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children","keywords":"Chimeric antigen receptor; Medicine; Immunotherapy; Cell therapy; Cancer; Leukemia; T cell; Cancer immunotherapy; Immunology; Cancer research; Immune system; Cell; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001250665,0.0008838873,0.001082921,0.001376003,0.000339686,0.001819451,0.0008847826,0.002250544,0.005175297],"category_scores_gemma":[0.001343627,0.0002700424,0.0005045393,0.001461489,0.0009971438,0.003141396,0.0009854748,0.004651832,0.003586029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001125119,"about_ca_system_score_gemma":0.001573889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009073158,"about_ca_topic_score_gemma":0.001130886,"domain_scores_codex":[0.9996308,0.00007293693,0.00003668615,0.00006558389,0.0001562212,0.00003773496],"domain_scores_gemma":[0.9994634,0.0002699699,0.00004570084,0.0000185273,0.0001516009,0.00005077259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007877898,0.00006432587,0.0000869031,0.006798337,0.00003190964,0.0001811938,0.00007013854,0.0003008168,0.001920537,0.01267853,0.05612029,0.9216683],"study_design_scores_gemma":[0.00001304762,0.0000764572,0.0001413234,0.001966537,0.00002394498,0.0005276017,0.00003356255,0.00005361066,0.0002989518,0.002871839,0.9939848,0.000008393398],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000119465,0.9942987,0.000318842,0.001809964,0.000864173,0.000009258583,0.00001457825,0.00002010385,0.002544903],"genre_scores_gemma":[0.0009464468,0.9949351,0.00040453,0.001821728,0.0006083147,0.00001221315,0.00002739889,0.000004934093,0.00123938],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005175297,"threshold_uncertainty_score":0.01731306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.465282330056444,"score_gpt":0.6140640395132099,"score_spread":0.1487817094567658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}