{"id":"W3016853436","doi":"10.1016/j.cmet.2020.04.003","title":"SGLT-2 Inhibitors and Regenerative Cell Exhaustion","year":2020,"lang":"en","type":"letter","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Robarts Clinical Trials; St. Michael's Hospital; Western University","funders":"","keywords":"Progenitor cell; Empagliflozin; CD34; Stem cell; Internal medicine; Cancer research; Medicine; Chemistry; Type 2 diabetes; Endocrinology; Diabetes mellitus; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007926864,0.0004022644,0.0008076134,0.0001788062,0.00008883127,0.00004788811,0.00007023634,0.0005636872,0.0003877156],"category_scores_gemma":[0.00009147491,0.0003371953,0.0001657881,0.0001945204,0.0001100745,0.0000652829,0.00005913959,0.001277071,0.0003512825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003219451,"about_ca_system_score_gemma":0.0001175931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001816706,"about_ca_topic_score_gemma":1.287661e-7,"domain_scores_codex":[0.9982948,0.0001036176,0.0003394925,0.0005747191,0.0003675615,0.0003198286],"domain_scores_gemma":[0.9990602,0.00009682629,0.0001910942,0.0003338372,0.0001075094,0.0002105874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002377833,0.00002538244,0.00006209742,0.0004633798,0.0000429325,0.0001703407,0.0001899587,3.223547e-7,0.02781606,0.00001285955,0.9708095,0.0003834194],"study_design_scores_gemma":[0.001222564,0.00007394928,0.0001428794,0.00006899586,0.0007442802,0.00001080919,0.00005232659,0.00003547705,0.1226325,0.00008354188,0.8746538,0.0002788586],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.05328194,0.04044307,0.000181236,0.7903097,0.005720781,0.00158683,0.0001261452,0.0004524427,0.1078978],"genre_scores_gemma":[0.01092716,0.001115846,0.00173443,0.9070217,0.018727,0.00007255262,0.0008242949,0.0001270761,0.05944993],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.116712,"threshold_uncertainty_score":0.999908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01504589475048995,"score_gpt":0.2191484441073724,"score_spread":0.2041025493568825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}