{"id":"W3016869714","doi":"10.1016/j.phrs.2020.104819","title":"Glycogen synthase kinase-3: The missing link to aberrant circuit function in disorders of cognitive dysfunction?","year":2020,"lang":"en","type":"review","venue":"Pharmacological Research","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; W. Garfield Weston Foundation; University of Guelph","keywords":"Cognition; GSK-3; Neuroscience; Schizophrenia (object-oriented programming); Hippocampus; Glycogen synthase; Pathological; Bipolar disorder; Disease; Traumatic brain injury; Psychology; Medicine; Kinase; Biology; Psychiatry; Internal medicine; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001479835,0.000299382,0.0006305471,0.0001745977,0.0001812637,0.00004024357,0.0005445641,0.000347749,0.0004864509],"category_scores_gemma":[0.001218408,0.0001982808,0.0002680345,0.0009376084,0.0002602171,0.000004055254,0.0004200566,0.0009139111,0.00009454004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001060201,"about_ca_system_score_gemma":0.0006153614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002097656,"about_ca_topic_score_gemma":0.00001020078,"domain_scores_codex":[0.9967704,0.0009233596,0.0005278554,0.000707987,0.0005367887,0.0005335453],"domain_scores_gemma":[0.9986401,0.0006550245,0.0001284553,0.0001788841,0.000227875,0.0001696197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004132693,0.0001240557,0.00002115156,0.0007723931,0.00027537,0.00001869578,0.00005242922,0.000008683341,0.006153662,0.00001515484,0.00305813,0.989087],"study_design_scores_gemma":[0.0005245731,0.0006151657,0.00005456375,0.001457962,0.0002591648,0.000003702279,0.00005881746,0.00001280366,0.002164908,0.0002102809,0.9943452,0.0002928426],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001022425,0.9939386,0.0004492232,0.001095642,0.0003053924,0.001832113,0.00005260796,0.00001429024,0.001289664],"genre_scores_gemma":[0.04592006,0.9518563,0.00001761192,0.0002804653,0.0005293558,0.0008674368,0.000192117,0.00004041507,0.0002963099],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9912871,"threshold_uncertainty_score":0.8085657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1617927838951387,"score_gpt":0.4394626058502078,"score_spread":0.2776698219550691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}