{"id":"W3016889239","doi":"10.3747/co.27.5285","title":"Targeting T Cell Activation in Immuno-Oncology","year":2020,"lang":"en","type":"review","venue":"Current Oncology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"EMD Serono; Symphogen","keywords":"Immunotherapy; Medicine; T cell; Immune checkpoint; Blockade; Cancer immunotherapy; Immune system; Cancer research; Immunology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0008339755,0.0008336859,0.003663579,0.0006573434,0.0002085509,0.00002237959,0.0009105858,0.002030331,0.001109387],"category_scores_gemma":[0.0004033135,0.0007394569,0.0006604348,0.0006851821,0.00033341,0.0001507759,0.00036372,0.002788801,0.002394985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001470768,"about_ca_system_score_gemma":0.002214191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002738939,"about_ca_topic_score_gemma":0.000003453008,"domain_scores_codex":[0.9926814,0.003655506,0.001769046,0.0008867367,0.00006017993,0.0009470698],"domain_scores_gemma":[0.996425,0.001718486,0.001233937,0.0004938671,0.00008747989,0.00004121956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003258572,0.0007715581,0.000006111723,0.003468416,0.0002182265,0.00002323622,0.0006598933,4.877367e-7,0.002720644,0.00005098368,0.005594209,0.9861604],"study_design_scores_gemma":[0.001982275,0.0008156443,0.000002657499,0.002440091,0.0002743989,0.00008901874,0.000206129,0.000001057717,0.0004645857,0.00001989805,0.9930564,0.0006479101],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007247055,0.9903771,0.0000944815,0.0001407086,0.006035889,0.001352886,0.00003686139,0.0001311503,0.001758402],"genre_scores_gemma":[0.00009949311,0.9970758,0.00004259731,0.00008366165,0.0002218098,0.0004513178,0.001352952,0.0001065066,0.0005658416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9874621,"threshold_uncertainty_score":0.9998037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1013408634451007,"score_gpt":0.4027896828304705,"score_spread":0.3014488193853698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}