{"id":"W3016916744","doi":"10.1083/jcb.202001147","title":"Sterol biosensor reveals LAM-family Ltc1-dependent sterol flow to endosomes upon Arp2/3 inhibition","year":2020,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Université de Lausanne; University of Toronto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Endosome; Sterol; Cell biology; Endocytosis; Biology; Internalization; Golgi apparatus; Biophysics; Biochemistry; Cell; Endoplasmic reticulum; Intracellular; Cholesterol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000378016,0.0001804749,0.0002754993,0.00005831778,0.0000640607,0.00001454239,0.0002500027,0.0001872064,0.00003117061],"category_scores_gemma":[0.00003450998,0.0001243966,0.0001571309,0.00008238083,0.00004979333,0.000006452113,0.00005972513,0.0002099409,0.00003747708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001493513,"about_ca_system_score_gemma":0.00004464474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005225197,"about_ca_topic_score_gemma":0.00001263969,"domain_scores_codex":[0.9986769,0.0002551913,0.0004852367,0.0001955671,0.0001385849,0.0002485051],"domain_scores_gemma":[0.9991888,0.00002657379,0.0002697269,0.0002027855,0.0001444711,0.0001676092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000862193,0.00003961347,0.0003133958,0.00001880915,0.000048904,0.00001427434,0.0003057057,0.0001993309,0.9972246,0.00001075958,0.0001632967,0.0007991524],"study_design_scores_gemma":[0.001087852,0.002065494,0.0009465239,0.00001681752,0.00007649408,0.00005142658,0.0001898279,0.0000520109,0.9685291,0.00006606782,0.02675616,0.0001622341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841531,0.001030055,0.01237114,0.001557789,0.000274144,0.0002166336,0.00003345303,0.000007130769,0.0003565799],"genre_scores_gemma":[0.9953412,0.0007058783,0.0003677874,0.00260462,0.0006483592,0.000002588484,0.0001809855,0.00002045762,0.0001281678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02869547,"threshold_uncertainty_score":0.5072744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435769976964776,"score_gpt":0.2236866339074955,"score_spread":0.2093289341378477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}