{"id":"W3016922132","doi":"10.1182/blood.v130.suppl_1.1845.1845","title":"Superior Efficacy of Carfilzomib and Dexamethasone (Kd56) Vs Bortezomib and Dexamethasone (Vd) in Multiple Myeloma (MM) Patients with Moderate or Serious Renal Failure: A Subgroup Analysis of the Phase 3 Endeavor Study","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"","keywords":"Carfilzomib; Medicine; Dexamethasone; Multiple myeloma; Internal medicine; Hazard ratio; Bortezomib; Clinical endpoint; Renal function; Creatinine; Adverse effect; Urology; Surgery; Confidence interval; Gastroenterology; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0027543,0.0009984709,0.002952515,0.0005493933,0.0003324553,0.001203348,0.0005576215,0.0009547963,0.001723467],"category_scores_gemma":[0.002654501,0.0003339046,0.005780417,0.0006714864,0.0004189135,0.0005651563,0.0005130816,0.001154156,0.0002033545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000491593,"about_ca_system_score_gemma":0.0007227437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007018616,"about_ca_topic_score_gemma":0.001670082,"domain_scores_codex":[0.9982966,0.0008496192,0.000269146,0.0002795109,0.0001467343,0.0001583934],"domain_scores_gemma":[0.9985741,0.0005669361,0.000346697,0.0001831731,0.00007300542,0.0002561716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8345705,0.001330325,0.0973546,0.0008734231,0.03128568,0.0002973355,0.0001438526,0.0009670615,0.005599397,0.0001191156,0.001099672,0.02635907],"study_design_scores_gemma":[0.2814661,0.1217043,0.510422,0.0003491479,0.06755759,0.001318208,0.0006714903,0.005716929,0.00349974,0.001271169,0.005843135,0.0001802252],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917049,0.006424011,0.0002348329,0.0001944701,0.0001162384,0.0002299524,0.0006221684,0.00001153908,0.000461927],"genre_scores_gemma":[0.9981751,0.0005177579,0.000145014,0.0001635836,0.00009869655,0.0001117748,0.0006051447,0.000004569897,0.0001783576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002952515,"threshold_uncertainty_score":0.0145663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02472076559773465,"score_gpt":0.2989913116747137,"score_spread":0.274270546076979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}