{"id":"W3016939709","doi":"10.1038/s41523-020-0156-0","title":"Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer","year":2020,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of British Columbia; Spinal Cord Injury BC; National Circus School; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; BC Cancer Agency","funders":"National Center for Research Resources; Daiichi Sankyo Europe; National Cancer Institute; Medical Research Council; Stand Up To Cancer; National Institutes of Health; Rosetrees Trust; CRUK Lung Cancer Centre of Excellence; National Institute for Health and Care Research; University College London; Wellcome Trust; Cancer Research UK; Wallace H. Coulter Foundation; Myriad Genetics; Francis Crick Institute; Georgia Clinical and Translational Science Alliance; Susan G. Komen; Prostate Cancer Foundation; AstraZeneca; U.S. Department of Defense; Eli Lilly and Company; Case Western Reserve University; National Breast Cancer Foundation; U.S. Department of Veterans Affairs; Breast Cancer Alliance; Pfizer; Amgen; European Commission; DOD Peer Reviewed Cancer Research Program; Breast Cancer Research Foundation","keywords":"Breast cancer; Cancer; Medicine; Stromal cell; Breast tumor; Pathology; Stromal tumor; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002004894,0.0003163875,0.00054736,0.0001594769,0.00006439595,0.00008641547,0.0001706511,0.0001176921,0.002001315],"category_scores_gemma":[0.00002032522,0.0002902933,0.0001252294,0.0007898223,0.0001143947,0.0003775294,0.0000513493,0.0003779042,0.00001094436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00116609,"about_ca_system_score_gemma":0.001301761,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01464209,"about_ca_topic_score_gemma":0.001724028,"domain_scores_codex":[0.9978503,0.00007005092,0.0005677193,0.0005329175,0.0003919833,0.0005870298],"domain_scores_gemma":[0.9992552,0.00005330696,0.000177571,0.0002084581,0.0000924913,0.0002129333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002825296,0.0001301487,0.8261437,0.000235993,0.00008862274,0.0001864586,0.00076593,0.000199043,0.08256759,0.000009245428,0.0006150115,0.08623292],"study_design_scores_gemma":[0.006242288,0.00005682341,0.9856553,0.001438358,0.00004480347,0.0003442893,0.0006089952,0.002290317,0.002062231,0.000005214559,0.0009021535,0.000349236],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805284,0.00259635,0.00001513727,0.01480058,0.0003033063,0.0003820315,0.0002388067,0.00008463246,0.001050779],"genre_scores_gemma":[0.9916757,0.0003532864,0.0001916797,0.006733452,0.0007862942,0.000145595,0.00001420473,0.0000565241,0.00004323743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1595116,"threshold_uncertainty_score":0.9999549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998069372488021,"score_gpt":0.3012786581673034,"score_spread":0.2812979644424232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}