{"id":"W3016961162","doi":"10.26508/lsa.202000707","title":"Robust production of uniform human cerebral organoids from pluripotent stem cells","year":2020,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; Krembil Foundation; Canada Research Chairs","keywords":"Organoid; Induced pluripotent stem cell; Biology; Neuroscience; Cell type; Human brain; Stem cell; Cell biology; Human Induced Pluripotent Stem Cells; Cell; Computational biology; Gene; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002980542,0.000147442,0.0001656291,0.00003140113,0.0001833705,0.00004467581,0.0008507725,0.00007767009,0.00004606346],"category_scores_gemma":[0.00008481766,0.000138507,0.00005875304,0.0005413175,0.0005552256,0.0000271161,0.0003292991,0.0001294429,0.00006310767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003026349,"about_ca_system_score_gemma":0.0003034992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003979219,"about_ca_topic_score_gemma":0.00001363292,"domain_scores_codex":[0.9979315,0.0000377047,0.0002776809,0.000754013,0.0006035388,0.0003955015],"domain_scores_gemma":[0.998861,0.00000502669,0.0001349824,0.0004868385,0.0002158772,0.0002962685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003116945,0.00003942017,0.002348918,0.00003101942,0.00001177973,0.000001698025,0.0001073788,0.001816043,0.9938916,0.00003231242,0.0013602,0.0003284854],"study_design_scores_gemma":[0.0002297759,0.0002037718,0.002572536,0.00002027887,0.000005941893,8.965307e-7,0.0001606637,0.0007072976,0.9920039,0.00001408728,0.003919598,0.0001613185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965724,0.0002724427,0.0007016365,0.001412253,0.0002882814,0.0002715182,0.00002313744,0.00001911387,0.0004392357],"genre_scores_gemma":[0.9966503,0.0001026904,0.001385693,0.000328835,0.0003545316,0.000007919243,0.00001924179,0.00001611728,0.001134638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002559398,"threshold_uncertainty_score":0.5648153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04146240400301712,"score_gpt":0.260877856162268,"score_spread":0.2194154521592509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}