{"id":"W3016961162","doi":"10.26508/lsa.202000707","title":"Robust production of uniform human cerebral organoids from pluripotent stem cells","year":2020,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; Krembil Foundation; Canada Research Chairs","keywords":"Organoid; Induced pluripotent stem cell; Biology; Neuroscience; Cell type; Human brain; Stem cell; Cell biology; Human Induced Pluripotent Stem Cells; Cell; Computational biology; Gene; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001315959,0.0005306876,0.0004002921,0.0006292145,0.0003435754,0.0008885814,0.0004742777,0.000484528,0.001975885],"category_scores_gemma":[0.001028437,0.0003173345,0.0004641756,0.0004254289,0.0003923716,0.0004300661,0.0009266501,0.001158453,0.001469185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003367286,"about_ca_system_score_gemma":0.0006967886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006518489,"about_ca_topic_score_gemma":0.001256468,"domain_scores_codex":[0.9995483,0.00006256253,0.00008270991,0.0001038357,0.000158753,0.0000439512],"domain_scores_gemma":[0.9993153,0.0001619816,0.0001206376,0.0001675377,0.0001488793,0.00008567671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006559875,0.00002141972,0.000378651,0.0001088073,0.0000167026,0.0002342146,0.0001011218,0.001063339,0.9882886,0.001254731,0.0006576659,0.007808974],"study_design_scores_gemma":[0.00001869176,0.0001353342,0.001033454,0.0000356672,0.00004039742,0.000368316,0.00005075173,0.001919902,0.9750503,0.0003568133,0.02097382,0.00001649277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.330563,0.004655913,0.6320055,0.0006749918,0.0004584379,0.002339108,0.01118501,0.002783479,0.0153345],"genre_scores_gemma":[0.7198977,0.005398303,0.2496171,0.0002721958,0.00006109092,0.001488377,0.01277649,0.0006718991,0.009816739],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001975885,"threshold_uncertainty_score":0.006959558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04146240400301712,"score_gpt":0.260877856162268,"score_spread":0.2194154521592509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}