{"id":"W3016991223","doi":"10.1096/fasebj.2020.34.s1.04515","title":"Loss‐ And Gain of Function Mutations in the Type 1 IP3 Receptor (IP3R1) Modify Agonist‐Evoked Vasoactive Responses in Cerebral and Skeletal Muscle Resistance Arteries From Adult Mice","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Vasoconstriction; Endocrinology; Agonist; Internal medicine; Transient receptor potential channel; Wild type; Biology; Receptor; Mutant; Chemistry; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005122776,0.001239053,0.0005871867,0.00113926,0.0004469367,0.0007419707,0.0008532046,0.001327082,0.003975669],"category_scores_gemma":[0.0002634138,0.0006906715,0.0009081422,0.0003329996,0.0009810106,0.0005021251,0.000560093,0.002282161,0.001446926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004895514,"about_ca_system_score_gemma":0.0003461125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001056123,"about_ca_topic_score_gemma":0.001537788,"domain_scores_codex":[0.9993908,0.0000733199,0.00009398761,0.0001636051,0.0001301058,0.0001481526],"domain_scores_gemma":[0.9994223,0.0001027848,0.0002267407,0.00004489917,0.00002674627,0.0001766288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002171348,0.0001230763,0.0001416806,0.00004486466,0.00001868998,0.0002473631,0.00005131059,0.00009647657,0.9975899,0.0002992454,0.0001166469,0.001053528],"study_design_scores_gemma":[0.0002541749,0.001110333,0.008231005,0.00004985997,0.0001564713,0.002097825,0.0001200373,0.00179351,0.9797795,0.0001818387,0.00619107,0.00003426231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837551,0.0009951318,0.008403891,0.0003892886,0.0001057222,0.0001698805,0.003240227,0.0006640381,0.002276786],"genre_scores_gemma":[0.9697953,0.001915639,0.00882985,0.0003303231,0.00007068043,0.0004398686,0.003402652,0.0005005569,0.01471507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003975669,"threshold_uncertainty_score":0.01329988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138039643740895,"score_gpt":0.2301305150079552,"score_spread":0.2163265506338657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}