{"id":"W3017010761","doi":"10.1002/pep2.24165","title":"Therapeutic peptides targeting the Ras superfamily","year":2020,"lang":"en","type":"article","venue":"Peptide Science","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Department of Biochemistry, University of Cambridge; Biotechnology and Biological Sciences Research Council; AstraZeneca","keywords":"Ras superfamily; GTPase; Small molecule; Computational biology; Drug discovery; SUPERFAMILY; Biology; Bioinformatics; Cell biology; Biochemistry; Gene; Enzyme; GTP'","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009580659,0.0003196339,0.0002087332,0.0001945008,0.00009607684,0.0002667201,0.0001538395,0.0003144197,0.002361381],"category_scores_gemma":[0.000087049,0.00004831485,0.0001351193,0.0001408561,0.0001112703,0.0002190457,0.0002017855,0.0006666489,0.0008945108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001790807,"about_ca_system_score_gemma":0.0001073387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001444752,"about_ca_topic_score_gemma":0.000137513,"domain_scores_codex":[0.9999558,0.000008488604,0.000003292066,0.0000083489,0.00001430008,0.000009751084],"domain_scores_gemma":[0.9999751,0.000004735488,0.000005860516,0.000001079616,0.000006998077,0.000006196323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004383448,0.0001736097,0.0001799504,0.002278424,0.0000380419,0.0008539928,0.00006388841,0.001078494,0.7716829,0.006048782,0.006781796,0.2103818],"study_design_scores_gemma":[0.0001999405,0.002726787,0.001581049,0.0003393097,0.00008015086,0.003603182,0.00006538061,0.001408366,0.4598352,0.00240548,0.5277187,0.00003648483],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2324087,0.6901649,0.02155463,0.002538171,0.003160255,0.0002420809,0.0007175445,0.0004065556,0.04880723],"genre_scores_gemma":[0.6739657,0.2854309,0.00794322,0.001525362,0.0009146917,0.0001825185,0.000651536,0.00003903021,0.02934708],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002361381,"threshold_uncertainty_score":0.007899642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02129696566895483,"score_gpt":0.2552996469350029,"score_spread":0.2340026812660481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}