{"id":"W3017104109","doi":"10.1096/fasebj.2020.34.s1.04464","title":"“Smac”ing the Life out of XIAP","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agricultural Research Institute of Ontario","funders":"","keywords":"XIAP; Inhibitor of apoptosis; Oncolytic virus; Apoptosis; Caspase; Cell biology; Cancer cell; Immune system; Biology; Chemistry; Cancer research; Biochemistry; Programmed cell death; Immunology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000769434,0.0003202699,0.0002548764,0.0001384916,0.0005350201,0.0007161666,0.0004154162,0.0005260918,0.01290007],"category_scores_gemma":[0.0001505001,0.0002299049,0.0004010218,0.0001710254,0.0004476202,0.0008130093,0.0004647109,0.0006473868,0.002744878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003569203,"about_ca_system_score_gemma":0.000502166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001374085,"about_ca_topic_score_gemma":0.001067128,"domain_scores_codex":[0.9999416,0.000008609678,0.000002247275,0.0000164273,0.00001892732,0.0000121586],"domain_scores_gemma":[0.9999607,0.000003885589,0.000007377097,0.000007582161,0.00000755214,0.00001302729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005047499,0.0001150812,0.001936607,0.0007345469,0.00009526903,0.001324072,0.0004440655,0.05169677,0.5420957,0.279776,0.04216162,0.07911561],"study_design_scores_gemma":[0.0001007777,0.0003414144,0.001748271,0.0001412484,0.00006206628,0.001275409,0.0002724256,0.1658102,0.1731119,0.05318094,0.6038525,0.0001029763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.3383001,0.008897251,0.2907917,0.006736123,0.002630043,0.0002618489,0.002367537,0.004908024,0.3451073],"genre_scores_gemma":[0.820165,0.004602871,0.06871627,0.001376874,0.0001304219,0.0002030289,0.001762815,0.0003317299,0.102711],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01290007,"threshold_uncertainty_score":0.04315495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215365328592226,"score_gpt":0.2369777066719711,"score_spread":0.2148240533860489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}