{"id":"W3017121724","doi":"10.1111/jphp.13269","title":"Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti-inflammatory molecule PH46A","year":2020,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Enterprise Ireland; Trinity College Dublin; Wellcome Trust; Wellcome","keywords":"Indane; Chemistry; Cytotoxicity; Cytokine; Nitric oxide; In vitro; Biochemistry; Cell culture; In silico; Mechanism of action; In vivo; Tumor necrosis factor alpha; Lead compound; Pharmacology; Stereochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008099421,0.0002671772,0.0001174647,0.0001304109,0.00006779649,0.0001161319,0.0001181377,0.0002064622,0.002441886],"category_scores_gemma":[0.00006022548,0.00007404177,0.0001509838,0.00007140199,0.0001142565,0.0002897401,0.0001042307,0.0004161411,0.0003997674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008804555,"about_ca_system_score_gemma":0.00007381097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001118588,"about_ca_topic_score_gemma":0.0001801695,"domain_scores_codex":[0.9999743,0.000004648703,0.000001224237,0.000005384245,0.000006871191,0.000007640706],"domain_scores_gemma":[0.9999715,0.000005200649,0.0000098966,0.000003020285,0.000004501972,0.000005820309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001302988,0.00003844352,0.0001465091,0.0001694738,0.000004029775,0.0000950942,0.00002405523,0.0004717108,0.9940313,0.0003101725,0.00006795415,0.0045109],"study_design_scores_gemma":[0.00002110958,0.001585452,0.00222876,0.00002812548,0.00001696809,0.0005776731,0.00006317958,0.001570093,0.9860596,0.0003155056,0.007521682,0.00001193593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737551,0.01194661,0.006333861,0.0003381506,0.00005965242,0.00007227649,0.0005024495,0.00005055427,0.006941266],"genre_scores_gemma":[0.9875571,0.004911372,0.003700426,0.0001431195,0.00003108784,0.00002757878,0.0002466867,0.000007377871,0.003375359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002441886,"threshold_uncertainty_score":0.008168936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0143876957198409,"score_gpt":0.2934812373464709,"score_spread":0.27909354162663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}