{"id":"W3017153652","doi":"10.20944/preprints202004.0315.v1","title":"In Search of Preventative Strategies: Novel Anti-Inflammatory High-CBD <em>Cannabis Sativa</em> Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues","year":2020,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Lethbridge","funders":"","keywords":"Biology; Cannabidiol; Cannabis sativa; Inflammation; Pharmacology; Immunology; Medicine; Cannabis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003218384,0.00112688,0.002347394,0.00140753,0.0001430166,0.0001263208,0.001393452,0.00117582,0.003048904],"category_scores_gemma":[0.001943477,0.001114771,0.0005040813,0.001127552,0.0006059301,0.0006372228,0.003833513,0.003635738,0.0002629783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001595875,"about_ca_system_score_gemma":0.00554946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002115088,"about_ca_topic_score_gemma":0.0008933203,"domain_scores_codex":[0.9899229,0.001031501,0.002265583,0.002789845,0.002544637,0.001445536],"domain_scores_gemma":[0.9946099,0.0001461719,0.0008839675,0.002340262,0.000739347,0.001280334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002059638,0.001645441,0.05540352,0.007703898,0.0003110555,0.00118259,0.03421601,0.0119517,0.8816577,0.0004905435,0.002596284,0.000781639],"study_design_scores_gemma":[0.006023873,0.0002872371,0.6176097,0.003661268,0.00009620152,0.00004416085,0.006217869,0.0009002,0.3542499,0.002014667,0.007782562,0.001112264],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824353,0.0009247183,0.0004136013,0.009319169,0.0004273406,0.004756685,0.0002420253,0.0001800578,0.001301132],"genre_scores_gemma":[0.9906818,0.00134602,0.0005789176,0.0002876921,0.0003450562,0.0009521811,0.0002709317,0.0002096202,0.005327801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5622062,"threshold_uncertainty_score":0.9991302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0876913096636423,"score_gpt":0.3871408274469825,"score_spread":0.2994495177833402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}