{"id":"W3017184575","doi":"10.1101/2020.04.20.051540","title":"Lathosterol oxidase (sterol C5-desaturase) deletion confers resistance to amphotericin B and sensitivity to acidic stress in <i>Leishmania major</i>","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University at Buffalo; National Institutes of Health; McMaster University; Texas Tech University","keywords":"Sterol; Biology; Mutant; Leishmania; Lathosterol; Leishmania braziliensis; Microbiology; Ergosterol; Biochemistry; Antifungal drug; Kinetoplastida; Gene; Leishmaniasis; Genetics; Cutaneous leishmaniasis; Antifungal; Cholesterol; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001042611,0.0003718754,0.0001889612,0.0002830037,0.0001360586,0.000283675,0.0003086443,0.0003351929,0.001431483],"category_scores_gemma":[0.000104665,0.0002552801,0.0002752741,0.0001506592,0.0002631018,0.0001252869,0.0003396491,0.0004809629,0.000556052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973991,"about_ca_system_score_gemma":0.0001325772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001492407,"about_ca_topic_score_gemma":0.001526996,"domain_scores_codex":[0.9998462,0.00002689197,0.00002820389,0.00002622884,0.00003709701,0.00003535263],"domain_scores_gemma":[0.9997781,0.00003364128,0.00007626334,0.00002255318,0.00001472671,0.00007465595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004038815,0.00001134606,0.0000821237,0.000007472062,0.0000020723,0.00004018882,0.000008189919,0.00001722195,0.9996386,0.00002762432,0.000008809322,0.0001160528],"study_design_scores_gemma":[0.00002522731,0.0002665256,0.01101387,0.00001082638,0.00002199004,0.0007190034,0.00009769935,0.001570683,0.9841307,0.00004058037,0.002089254,0.00001370339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979458,0.0001391838,0.0008215781,0.00004773118,0.000009808856,0.00001609993,0.0004008939,0.00004843542,0.0005704356],"genre_scores_gemma":[0.9960476,0.0001197294,0.0009588478,0.00003436632,0.000005094529,0.00002052181,0.0009727819,0.0000472724,0.001793748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001492407,"threshold_uncertainty_score":0.004788816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966076437215568,"score_gpt":0.2555117642227012,"score_spread":0.2358509998505456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}