{"id":"W3017202750","doi":"10.3390/cells9040976","title":"The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem","year":2020,"lang":"en","type":"review","venue":"Cells","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":475,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Centre National de la Recherche Scientifique; Université Laval","keywords":"Osteosarcoma; Tumor microenvironment; Stromal cell; Medicine; Extracellular vesicles; Cancer research; Oncology; Bioinformatics; Immune system; Immunology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002385335,0.000533085,0.0009245864,0.001193546,0.000242567,0.001134374,0.0004358069,0.0008464362,0.001844477],"category_scores_gemma":[0.0002696354,0.0001692659,0.0003143891,0.0008176776,0.0003873662,0.0012796,0.0006127146,0.001205384,0.000984384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005477436,"about_ca_system_score_gemma":0.0008708407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006621605,"about_ca_topic_score_gemma":0.001255631,"domain_scores_codex":[0.9998914,0.00001740851,0.00001456384,0.00001795564,0.00004518189,0.00001346485],"domain_scores_gemma":[0.999897,0.00004731022,0.00001528084,0.000002781287,0.00002655357,0.0000110685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005902494,0.00004234699,0.000242687,0.0144335,0.00007504011,0.0004495941,0.00008765334,0.0004352313,0.005859913,0.008260448,0.01948788,0.9505666],"study_design_scores_gemma":[0.000006174618,0.00006583088,0.0005385103,0.001967506,0.00006051441,0.002283826,0.00007382305,0.0001061099,0.001066457,0.002129519,0.9916866,0.00001514717],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002020932,0.9981281,0.0001898273,0.0003187345,0.0001811922,0.000003413973,0.00001568652,0.000007891878,0.0009529727],"genre_scores_gemma":[0.0009131827,0.9981918,0.0001699207,0.0001209659,0.000105414,0.000003281429,0.00002146018,0.00000113809,0.0004728236],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001844477,"threshold_uncertainty_score":0.006170332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027572816166725,"score_gpt":0.2574580742029403,"score_spread":0.237182346041273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}