{"id":"W3017234934","doi":"10.1002/wnan.1628","title":"Image‐guided mathematical modeling for pharmacological evaluation of nanomaterials and monoclonal antibodies","year":2020,"lang":"en","type":"review","venue":"Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Nanomedicine; Drug delivery; Monoclonal antibody; Pharmacokinetics; Kinetics; Computational biology; Modalities; Pharmacology; Nanotechnology; Medicine; Biology; Nanoparticle; Antibody; Materials science; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003749048,0.0007603741,0.004768088,0.0004010912,0.0001971442,0.00004286749,0.000543708,0.0007134241,0.0004879353],"category_scores_gemma":[0.0007597586,0.0005149575,0.0003998885,0.0003553371,0.0009146822,0.0001902753,0.001380096,0.0003281246,0.0001121517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001285695,"about_ca_system_score_gemma":0.0002518068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001168372,"about_ca_topic_score_gemma":3.851675e-7,"domain_scores_codex":[0.9946679,0.0006917052,0.002627527,0.001109906,0.0003678656,0.0005350291],"domain_scores_gemma":[0.9974939,0.0004473889,0.001133507,0.0004909127,0.0002524353,0.0001818516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000127578,0.0001802568,3.016842e-7,0.03009861,0.0001542585,0.00002624296,0.000166304,0.000001560918,0.1226318,0.0002058603,0.001443935,0.8449633],"study_design_scores_gemma":[0.006899707,0.006071954,2.579713e-7,0.09445491,0.0241832,0.003119319,0.0003716933,0.04867718,0.03022143,0.009397399,0.7736275,0.002975454],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01062784,0.9823439,0.001038861,0.0006259365,0.0003640092,0.004609548,0.0002296564,0.0001232648,0.00003697791],"genre_scores_gemma":[0.0006440746,0.9892113,0.00867644,0.00004602145,0.0002319014,0.00101209,0.00009678741,0.00006253684,0.00001889931],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8419878,"threshold_uncertainty_score":0.9997302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1088003930365145,"score_gpt":0.4072355861791967,"score_spread":0.2984351931426822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}