{"id":"W3017244061","doi":"10.1002/cpdd.788","title":"Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine (a CYP1A2 Substrate) in Patients With <i>BRAF</i><sup>V600</sup> Mutation–Positive Malignancies","year":2020,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Pharmacokinetics; Vemurafenib; Pharmacology; Mutation; Oncology; Internal medicine; Cancer research; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001188997,0.0006086488,0.001306321,0.0001733637,0.0001833748,0.0005070816,0.0002956238,0.000441695,0.0006648109],"category_scores_gemma":[0.001786025,0.0003744988,0.001105206,0.0001877537,0.0003973718,0.0005154914,0.0001755541,0.0014069,0.000112856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005657311,"about_ca_system_score_gemma":0.0005318421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004321228,"about_ca_topic_score_gemma":0.0007350056,"domain_scores_codex":[0.9993851,0.0003398529,0.00003139401,0.0001035889,0.00006832654,0.00007156389],"domain_scores_gemma":[0.9990163,0.000361269,0.00030753,0.00008014636,0.00003822375,0.0001965734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.663625,0.01871086,0.03634991,0.0003001149,0.002689895,0.0002747547,0.0002560306,0.009564163,0.1175892,0.0001440791,0.0008927703,0.1496033],"study_design_scores_gemma":[0.08254845,0.7430032,0.1340164,0.00002519327,0.001326345,0.0006120664,0.00009320005,0.01213379,0.02429578,0.0001933311,0.001680521,0.00007165153],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992199,0.0003963559,0.0001585703,0.00003345275,0.00001322652,0.00003271543,0.00003858001,0.00001105858,0.00009612765],"genre_scores_gemma":[0.999374,0.0001223896,0.0002731246,0.00003296126,0.00002164301,0.00003615621,0.00005409092,0.000003682514,0.00008190543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306321,"threshold_uncertainty_score":0.006288052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806922812262594,"score_gpt":0.2851740033891128,"score_spread":0.2671047752664868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}