{"id":"W3017244061","doi":"10.1002/cpdd.788","title":"Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine (a CYP1A2 Substrate) in Patients With <i>BRAF</i><sup>V600</sup> Mutation–Positive Malignancies","year":2020,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Pharmacokinetics; Vemurafenib; Pharmacology; Mutation; Oncology; Internal medicine; Cancer research; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006724622,0.0002078367,0.0004619129,0.00005716635,0.00002229694,0.00000248577,0.0002639523,0.0001233885,0.00003564781],"category_scores_gemma":[0.0001857295,0.0001459862,0.00007689869,0.0002237605,0.0002731512,0.000004918107,0.0001191057,0.0002059827,0.000003883611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001982168,"about_ca_system_score_gemma":0.0001680401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005196146,"about_ca_topic_score_gemma":0.000006001005,"domain_scores_codex":[0.9978158,0.0005134566,0.0009122474,0.0003434926,0.0001909699,0.0002240457],"domain_scores_gemma":[0.9988157,0.000472081,0.0003532924,0.0001311786,0.0001448885,0.0000828648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0141867,0.003701942,0.3469602,0.0004881778,0.0006052979,0.0000766475,0.003946029,0.004264952,0.6177489,0.00004424074,0.002848211,0.00512881],"study_design_scores_gemma":[0.006470987,0.003075024,0.08383639,0.00007340326,0.00005145332,7.804169e-7,0.00006454289,0.00007540613,0.9057941,0.000003845179,0.0004057312,0.000148324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984789,0.00008480599,0.00001485896,0.0002824851,0.0001312759,0.0007617009,0.00003173586,0.000004480346,0.0002097044],"genre_scores_gemma":[0.9988315,0.00003837059,0.0001847974,0.0007115816,0.00005814229,0.00005031235,0.00009252293,0.00001721476,0.00001562987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2880453,"threshold_uncertainty_score":0.5953144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806922812262594,"score_gpt":0.2851740033891128,"score_spread":0.2671047752664868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}