{"id":"W3017247589","doi":"10.1016/j.chom.2020.03.024","title":"VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA","year":2020,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institutes of Health; Canada Research Chairs; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Rockefeller University; National Center for Advancing Translational Sciences; Fonds de Recherche du Québec - Santé","keywords":"Biology; Epitope; Virology; Vesicular stomatitis virus; Neutralization; Antibody; Glycan; Neutralizing antibody; Virus; Viral envelope; Immunoglobulin G; Glycoprotein; Molecular biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001158305,0.0003071258,0.0001276059,0.0002242222,0.0001763063,0.0003467278,0.0002958104,0.0004162732,0.003237303],"category_scores_gemma":[0.000148908,0.0001509619,0.0001885149,0.000126106,0.0002030011,0.0001881941,0.0002471077,0.0007959225,0.000520152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006558873,"about_ca_system_score_gemma":0.0001969699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00141672,"about_ca_topic_score_gemma":0.00232324,"domain_scores_codex":[0.9998471,0.000019421,0.000004757581,0.00003160668,0.00002542297,0.00007170445],"domain_scores_gemma":[0.9999354,0.00001551322,0.000008169507,0.000008725079,0.00001147091,0.00002072298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001646005,0.00003308935,0.0004462579,0.00001465379,0.000006908745,0.00003176738,0.00001656077,0.00008270046,0.9970863,0.0003547304,0.0001337755,0.001628664],"study_design_scores_gemma":[0.00005285615,0.0005052411,0.01974522,0.00002585183,0.00003373464,0.0007483564,0.0001475651,0.005426371,0.9673368,0.0004711386,0.005496763,0.00001006446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919682,0.0004131265,0.002169508,0.0001026795,0.00002610178,0.00001754093,0.0002517656,0.00005494618,0.004996017],"genre_scores_gemma":[0.9930717,0.0002458047,0.002158866,0.0001340164,0.000009579917,0.00001772498,0.0004941883,0.00002121695,0.003846868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003237303,"threshold_uncertainty_score":0.01082987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801150749991083,"score_gpt":0.2538815492964084,"score_spread":0.2358700417964976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}